Elevated level of follicular fluid vascular endothelial growth factor is a marker of diminished pregnancy potential

Chad I. Friedman, David B. Seifer, Elizabeth A. Kennard, Laura Arbogast, Baha Alak, Douglas R. Danforth

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

Objective: To evaluate whether differences in follicular fluid vascular endothelial growth factor (FF VEGF) concentrations are observed between women achieving a clinical pregnancy and those failing to conceive. Design: Retrospective chart review and analysis of FF VEGF concentrations. Setting: University teaching center. Patient(s): Fifty-seven women ≤42 years of age undergoing follicular aspiration in preparation for IVF or GIFT. Intervention(s): Analysis of FF VEGF concentrations and chart review of a single IVF or GIFT cycle. Main Outcome Measure(s): Follicular fluid VEGF concentrations, clinical pregnancy rate, age, ampules of gonadotropins used, oocytes retrieved, peak estradiol serum concentrations, day 3 FSH levels, and fertilization rate. Result(s): Women who did not conceive had higher FF VEGF concentrations than women achieving a clinical pregnancy (4,409 + 2,387 versus 2,793 ± 1,180 pg/mL: P < .001). A negative correlation was observed between FF VEGF concentrations and peak estradiol levels and number of oocytes retrieved. A positive correlation was found for FF VEGF and patient's age and ampules of gonadotropins used. Conclusion(s): Elevated FF VEGF concentrations are associated with poor conception rates after IVF or GIFT.

Original languageEnglish (US)
Pages (from-to)836-839
Number of pages4
JournalFertility and sterility
Volume70
Issue number5
DOIs
StatePublished - Nov 1 1998

Keywords

  • Follicular fluid
  • In vitro fertilization
  • Ovarian aging
  • VEGF

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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