Elephant endotheliotropic herpesvirus 5, a newly recognized elephant herpesvirus associated with clinical and subclinical infections in captive asian elephants (elephas maximus)

Lisa Atkins, Jian Chao Zong, Jie Tan, Alicia Mejia, Sarah Y. Heaggans, Sally A. Nofs, Jeffrey Stanton, Joseph P. Flanagan, Lauren Howard, Erin Latimer, Martina R. Stevens, Daryl S. Hoffman, Gary S. Hayward, Paul D. Ling

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Elephant endotheliotropic herpesviruses (EEHVs) can cause acute hemorrhagic disease with high mortality rates in Asian elephants (Elephas maximus). Recently, a new EEHV type known as EEHV5 has been described, but its prevalence and clinical significance remain unknown. In this report, an outbreak of EEHV5 infection in a herd of captive Asian elephants in a zoo was characterized. In February 2011, a 42-yr-old wild-born female Asian elephant presented with bilaterally swollen temporal glands, oral mucosal hyperemia, vesicles on the tongue, and generalized lethargy. The elephant had a leukopenia and thrombocytopenia. She was treated with flunixin meglumine, famciclovir, and fluids. Clinical signs of illness resolved gradually over 2 wk, and the white blood cell count and platelets rebounded to higher-than-normal values. EEHV5 viremia was detectable starting 1 wk before presentation and peaked at the onset of clinical illness. EEHV5 shedding in trunk secretions peaked after viremia resolved and continued for more than 2 mo. EEHV5 trunk shedding from a female herd mate without any detectable viremia was detected prior to onset of clinical disease in the 42-yr-old elephant, indicating reactivation rather than primary infection in this elephant. Subsequent EEHV5 viremia and trunk shedding was documented in the other five elephants in the herd, who remained asymptomatic, except for 1 day of temporal gland swelling in an otherwise-healthy 1-yr-old calf. Unexpectedly, the two elephants most recently introduced into the herd 40 mo previously shed a distinctive EEHV5 strain from that seen in the other five elephants. This is the first report to document the kinetics of EEHV5 infection in captive Asian elephants and to provide evidence that this virus can cause illness in some animals.

Original languageEnglish (US)
Pages (from-to)136-143
Number of pages8
JournalJournal of Zoo and Wildlife Medicine
Volume44
Issue number1
DOIs
StatePublished - Mar 2013
Externally publishedYes

Fingerprint

Elephantid herpesvirus 1
Elephas maximus
Asymptomatic Infections
Herpesviridae
Elephantidae
viremia
herds
infection
Viremia
flunixin
leukopenia
thrombocytopenia
tongue
zoos
leukocyte count
normal values
mouth
secretion
calves
Infection

Keywords

  • Asian elephant
  • elephant endotheliotropic herpesviruses
  • Elephas maximus
  • Proboscivirus
  • realtime PCR
  • viremia

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Elephant endotheliotropic herpesvirus 5, a newly recognized elephant herpesvirus associated with clinical and subclinical infections in captive asian elephants (elephas maximus). / Atkins, Lisa; Zong, Jian Chao; Tan, Jie; Mejia, Alicia; Heaggans, Sarah Y.; Nofs, Sally A.; Stanton, Jeffrey; Flanagan, Joseph P.; Howard, Lauren; Latimer, Erin; Stevens, Martina R.; Hoffman, Daryl S.; Hayward, Gary S.; Ling, Paul D.

In: Journal of Zoo and Wildlife Medicine, Vol. 44, No. 1, 03.2013, p. 136-143.

Research output: Contribution to journalArticle

Atkins, L, Zong, JC, Tan, J, Mejia, A, Heaggans, SY, Nofs, SA, Stanton, J, Flanagan, JP, Howard, L, Latimer, E, Stevens, MR, Hoffman, DS, Hayward, GS & Ling, PD 2013, 'Elephant endotheliotropic herpesvirus 5, a newly recognized elephant herpesvirus associated with clinical and subclinical infections in captive asian elephants (elephas maximus)', Journal of Zoo and Wildlife Medicine, vol. 44, no. 1, pp. 136-143. https://doi.org/10.1638/1042-7260-44.1.136
Atkins, Lisa ; Zong, Jian Chao ; Tan, Jie ; Mejia, Alicia ; Heaggans, Sarah Y. ; Nofs, Sally A. ; Stanton, Jeffrey ; Flanagan, Joseph P. ; Howard, Lauren ; Latimer, Erin ; Stevens, Martina R. ; Hoffman, Daryl S. ; Hayward, Gary S. ; Ling, Paul D. / Elephant endotheliotropic herpesvirus 5, a newly recognized elephant herpesvirus associated with clinical and subclinical infections in captive asian elephants (elephas maximus). In: Journal of Zoo and Wildlife Medicine. 2013 ; Vol. 44, No. 1. pp. 136-143.
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