Elements of a paracrine tubular renin-angiotensin system along the entire nephron

Andreas Rohrwasser, Terry Morgan, Harrison F. Dillon, Ling Zhao, Christopher W. Callaway, Elaine Hillas, Shuhua Zhang, Tong Cheng, Tadashi Inagami, Kenneth Ward, Daniel A. Terreros, Jean Marc Lalouel

Research output: Contribution to journalArticle

228 Citations (Scopus)

Abstract

The renin-angiotensin system is a major regulator of body sodium, predominantly through the actions of intrarenal angiotensin II of unclear origin. We show that polarized epithelium of the proximal tubule synthesizes and secretes angiotensinogen at its apical side and that the protein can be detected in urine as a function of dietary sodium. Furthermore, we demonstrate that renin is expressed and secreted in a restricted nephron segment, the connecting tubule, also in a sodium-dependent fashion. A paracrine renin-angiotensin system operating along the entire nephron may contribute to long-term arterial pressure regulation by integrating distant tubular sodium-reabsorbing functions.

Original languageEnglish (US)
Pages (from-to)1265-1274
Number of pages10
JournalHypertension
Volume34
Issue number6
StatePublished - Dec 1999
Externally publishedYes

Fingerprint

Nephrons
Renin-Angiotensin System
Sodium
Dietary Sodium
Angiotensinogen
Renin
Angiotensin II
Arterial Pressure
Epithelium
Urine
Proteins

Keywords

  • Angiotensinogen
  • Kidney
  • Renin
  • Renin-angiotensin system
  • Sodium, dietary

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Rohrwasser, A., Morgan, T., Dillon, H. F., Zhao, L., Callaway, C. W., Hillas, E., ... Lalouel, J. M. (1999). Elements of a paracrine tubular renin-angiotensin system along the entire nephron. Hypertension, 34(6), 1265-1274.

Elements of a paracrine tubular renin-angiotensin system along the entire nephron. / Rohrwasser, Andreas; Morgan, Terry; Dillon, Harrison F.; Zhao, Ling; Callaway, Christopher W.; Hillas, Elaine; Zhang, Shuhua; Cheng, Tong; Inagami, Tadashi; Ward, Kenneth; Terreros, Daniel A.; Lalouel, Jean Marc.

In: Hypertension, Vol. 34, No. 6, 12.1999, p. 1265-1274.

Research output: Contribution to journalArticle

Rohrwasser, A, Morgan, T, Dillon, HF, Zhao, L, Callaway, CW, Hillas, E, Zhang, S, Cheng, T, Inagami, T, Ward, K, Terreros, DA & Lalouel, JM 1999, 'Elements of a paracrine tubular renin-angiotensin system along the entire nephron', Hypertension, vol. 34, no. 6, pp. 1265-1274.
Rohrwasser A, Morgan T, Dillon HF, Zhao L, Callaway CW, Hillas E et al. Elements of a paracrine tubular renin-angiotensin system along the entire nephron. Hypertension. 1999 Dec;34(6):1265-1274.
Rohrwasser, Andreas ; Morgan, Terry ; Dillon, Harrison F. ; Zhao, Ling ; Callaway, Christopher W. ; Hillas, Elaine ; Zhang, Shuhua ; Cheng, Tong ; Inagami, Tadashi ; Ward, Kenneth ; Terreros, Daniel A. ; Lalouel, Jean Marc. / Elements of a paracrine tubular renin-angiotensin system along the entire nephron. In: Hypertension. 1999 ; Vol. 34, No. 6. pp. 1265-1274.
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