Electrophysiological measures of auditory processing in patients with multiple sclerosis

Robert L. Folmer, Michele M. Hutter, David J. Lilly, Jeffrey Shannon, Linda Casiana, Debra Wilmington, M. Samantha Lewis, Curtis Billings, Christine Krisky, Yosef A. Berlow, James Pollaro, William Rooney, Dennis Bourdette

Research output: Contribution to journalArticle

Abstract

Previous studies demonstrated that patients with multiple sclerosis (MS) experience more hearing loss than age-matched control subjects. Patients with MS also exhibit deficits processing auditory stimuli, including speech in a background of noise. These findings suggest that auditory deficits in the MS population can result from damage to central neural pathways in addition to peripheral hearing structures. To assess auditory processing functions in patients with MS, this study used auditory event-related potentials (AERPs)specifically, the auditory brain stem response (ABR) and long-latency AERPs including the P300. AERPs recorded from 20 patients with MS were compared to AERPs from 20 healthy control subjects. When ABR stimuli (clicks) were presented monaurally, there were no significant differences between groups in component latencies or amplitudes for waves I through V. However, binaural presentation of the same stimuli elicited wave V ABR components significantly greater in amplitude for the control group compared with the MS group. Long-latency AERP results showed no significant differences between groups for N100 latency and amplitude or for P300 latency. P300 component amplitude was significantly greater for control subjects compared with patients with MS. It is probable that neural degeneration and impaired neural transmission within the MS group contributed to these AERP results. AERPs are useful tools that can be used to assess peripheral and central auditory functions as well as cognitive processing abilities in patients with MS. AERPs could be used to evaluate neural integrity, disease progression, and treatment efficacy in this population.

Original languageEnglish (US)
Pages (from-to)274-282
Number of pages9
JournalSeminars in Hearing
Volume33
Issue number3
DOIs
StatePublished - 2012

Fingerprint

Multiple Sclerosis
Evoked Potentials
Brain Stem Auditory Evoked Potentials
P300 Event-Related Potentials
Neural Pathways
Aptitude
Hearing Loss
Synaptic Transmission
Population
Hearing
Reaction Time
Disease Progression
Noise
Healthy Volunteers
Control Groups

Keywords

  • AERP
  • auditory event-related potentials
  • evoked potentials
  • MS
  • multiple sclerosis

ASJC Scopus subject areas

  • Speech and Hearing

Cite this

Folmer, R. L., Hutter, M. M., Lilly, D. J., Shannon, J., Casiana, L., Wilmington, D., ... Bourdette, D. (2012). Electrophysiological measures of auditory processing in patients with multiple sclerosis. Seminars in Hearing, 33(3), 274-282. https://doi.org/10.1055/s-0032-1315726

Electrophysiological measures of auditory processing in patients with multiple sclerosis. / Folmer, Robert L.; Hutter, Michele M.; Lilly, David J.; Shannon, Jeffrey; Casiana, Linda; Wilmington, Debra; Lewis, M. Samantha; Billings, Curtis; Krisky, Christine; Berlow, Yosef A.; Pollaro, James; Rooney, William; Bourdette, Dennis.

In: Seminars in Hearing, Vol. 33, No. 3, 2012, p. 274-282.

Research output: Contribution to journalArticle

Folmer, RL, Hutter, MM, Lilly, DJ, Shannon, J, Casiana, L, Wilmington, D, Lewis, MS, Billings, C, Krisky, C, Berlow, YA, Pollaro, J, Rooney, W & Bourdette, D 2012, 'Electrophysiological measures of auditory processing in patients with multiple sclerosis', Seminars in Hearing, vol. 33, no. 3, pp. 274-282. https://doi.org/10.1055/s-0032-1315726
Folmer RL, Hutter MM, Lilly DJ, Shannon J, Casiana L, Wilmington D et al. Electrophysiological measures of auditory processing in patients with multiple sclerosis. Seminars in Hearing. 2012;33(3):274-282. https://doi.org/10.1055/s-0032-1315726
Folmer, Robert L. ; Hutter, Michele M. ; Lilly, David J. ; Shannon, Jeffrey ; Casiana, Linda ; Wilmington, Debra ; Lewis, M. Samantha ; Billings, Curtis ; Krisky, Christine ; Berlow, Yosef A. ; Pollaro, James ; Rooney, William ; Bourdette, Dennis. / Electrophysiological measures of auditory processing in patients with multiple sclerosis. In: Seminars in Hearing. 2012 ; Vol. 33, No. 3. pp. 274-282.
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