Electroencephalographic abnormalities following halothane anesthesia

Kim Burchiel, J. J. Stockard, R. K. Calverley, N. T. Smith, M. L. Scholl, R. I. Mazze

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In 7 subjects, serial EEGs, serum bromide determinations, and psychological tests were done prior to and following 13.83 ± 0.74 (SEM) MAC-hours of halothane anesthesia. Significant psychological impairment demonstrated 2 days following anesthesia in these subjects was absent 2 weeks following exposure to halothane. Nonspecific postanesthetic slowing of the EEG was found, qualitatively similar to but more marked than that following exposure to enflurane. Generalized EEG slowing, with a tendency toward posterior delta activity and significant reduction of frequency and amplitude of the alpha rhythm, persisted for 6 to 8 days following anesthesia. Rare sharp-wave activity developed in 3 subjects in the 1st week after halothane. A potentially psychoactive postanesthetic serum bromide level of 2.97 ± 0.17 mEq/L (SEM) was found 5 days following anesthesia. Electroencephalographic changes characteristic of mild bromide intoxication were absent, suggesting that the psychological impairment noted after halothane anesthesia is probably not due to this metabolite; these psychological changes are probably due instead to persistence in the circulation of unchanged halothane.

Original languageEnglish (US)
Pages (from-to)244-251
Number of pages8
JournalAnesthesia and Analgesia
Volume57
Issue number2
StatePublished - 1978
Externally publishedYes

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Halothane
Anesthesia
Bromides
Electroencephalography
Psychology
Alpha Rhythm
Enflurane
Psychological Tests
Serum

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Burchiel, K., Stockard, J. J., Calverley, R. K., Smith, N. T., Scholl, M. L., & Mazze, R. I. (1978). Electroencephalographic abnormalities following halothane anesthesia. Anesthesia and Analgesia, 57(2), 244-251.

Electroencephalographic abnormalities following halothane anesthesia. / Burchiel, Kim; Stockard, J. J.; Calverley, R. K.; Smith, N. T.; Scholl, M. L.; Mazze, R. I.

In: Anesthesia and Analgesia, Vol. 57, No. 2, 1978, p. 244-251.

Research output: Contribution to journalArticle

Burchiel, K, Stockard, JJ, Calverley, RK, Smith, NT, Scholl, ML & Mazze, RI 1978, 'Electroencephalographic abnormalities following halothane anesthesia', Anesthesia and Analgesia, vol. 57, no. 2, pp. 244-251.
Burchiel K, Stockard JJ, Calverley RK, Smith NT, Scholl ML, Mazze RI. Electroencephalographic abnormalities following halothane anesthesia. Anesthesia and Analgesia. 1978;57(2):244-251.
Burchiel, Kim ; Stockard, J. J. ; Calverley, R. K. ; Smith, N. T. ; Scholl, M. L. ; Mazze, R. I. / Electroencephalographic abnormalities following halothane anesthesia. In: Anesthesia and Analgesia. 1978 ; Vol. 57, No. 2. pp. 244-251.
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