Electrocoating carbon fiber microelectrodes with Nafion improves selectivity for electroactive neurotransmitters

M. P. Brazell, R. J. Kasser, K. J. Renner, J. Feng, B. Moghaddam, R. N. Adams

Research output: Contribution to journalArticlepeer-review

124 Scopus citations

Abstract

A method which improves carbon fiber microelectrode selectivity for cationic amines by electrocoating the fiber with a thin film of the ionic polymer, Nafion, is described. The selectivity and response speed of these electrodes for the detection of electroactive cationic and anionic species found in brain extracellular fluid was evaluated using differential pulse voltammetry and chronoamperometry and compared to uncoated fibers. Carbon fiber microelectrodes electrocoated with Nafion are highly sensitive to cationic amines such as dopamine and serotonin and have minimal sensitivity to anions such as ascorbic acid and uric acid at physiological concentrations.

Original languageEnglish (US)
Pages (from-to)167-172
Number of pages6
JournalJournal of Neuroscience Methods
Volume22
Issue number2
DOIs
StatePublished - Dec 1987

Keywords

  • Carbon fiber microelectrode
  • Chronoamperometry
  • Differential pulse voltammetry
  • Electrocoating
  • Nafion
  • Selectivity

ASJC Scopus subject areas

  • Neuroscience(all)

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