Electrocardiographic abnormalities associated with the metabolic syndrome and its components: The multi-ethnic study of atherosclerosis

Imo A. Ebong, Alain G. Bertoni, Elsayed Z. Soliman, Mengye Guo, Christopher Sibley, Yii Der I Chen, Jerome I. Rotter, Yi Chun Chen, David C. Goff

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: The association between metabolic syndrome and electrocardiographic (ECG) abnormalities is not well established. Methods: ECG tracings of 6,765 men and women aged 45-84 years, free of clinical cardiovascular disease, from the Multi-Ethnic Study of Atherosclerosis were obtained (2000-2002) and classified as normal or having major or minor abnormalities. We evaluated the associations of metabolic syndrome and its components with ECG abnormalities, adjusting for age, ethnicity, and gender and testing for effect modification by ethnicity and gender. Results: The associations of metabolic syndrome, hypertension, and high triglycerides with ECG abnormalities varied significantly by gender. In males, metabolic syndrome and hypertension were significantly associated with major ECG abnormality [1.69 (1.33-2.13), and 2.22 (1.72-2.86), respectively] after adjusting for ethnicity and gender. Hypertension was also associated significantly with minor ECG abnormality in males after adjusting for age and ethnicity. In females, metabolic syndrome and hypertension were significantly associated with major [1.84 (1.44-2.37), and 1.68 (1.27-2.22), respectively] and minor [1.38 (1.19-1.59), and 1.53 (1.32-1.79), respectively] ECG abnormalities after adjusting for age and ethnicity. High triglycerides were only significantly associated with major ECG abnormality in females after adjusting for age and ethnicity. After adjusting for age, ethnicity, and gender, central obesity and high fasting blood glucose were significantly associated with major and minor ECG abnormalities, whereas low high-density lipoprotein cholesterol was significantly associated with major ECG abnormality only. Conclusions: Metabolic syndrome and its components are associated with major and/or minor ECG abnormalities. The relationship of metabolic syndrome, hypertension, and high triglycerides with ECG abnormalities varied according to gender.

Original languageEnglish (US)
Pages (from-to)92-97
Number of pages6
JournalMetabolic Syndrome and Related Disorders
Volume10
Issue number2
DOIs
StatePublished - Apr 1 2012
Externally publishedYes

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Atherosclerosis
Hypertension
Triglycerides
Abdominal Obesity
LDL Cholesterol
HDL Cholesterol
Blood Glucose
Fasting
Cardiovascular Diseases

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Electrocardiographic abnormalities associated with the metabolic syndrome and its components : The multi-ethnic study of atherosclerosis. / Ebong, Imo A.; Bertoni, Alain G.; Soliman, Elsayed Z.; Guo, Mengye; Sibley, Christopher; Chen, Yii Der I; Rotter, Jerome I.; Chen, Yi Chun; Goff, David C.

In: Metabolic Syndrome and Related Disorders, Vol. 10, No. 2, 01.04.2012, p. 92-97.

Research output: Contribution to journalArticle

Ebong, Imo A. ; Bertoni, Alain G. ; Soliman, Elsayed Z. ; Guo, Mengye ; Sibley, Christopher ; Chen, Yii Der I ; Rotter, Jerome I. ; Chen, Yi Chun ; Goff, David C. / Electrocardiographic abnormalities associated with the metabolic syndrome and its components : The multi-ethnic study of atherosclerosis. In: Metabolic Syndrome and Related Disorders. 2012 ; Vol. 10, No. 2. pp. 92-97.
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T2 - The multi-ethnic study of atherosclerosis

AU - Ebong, Imo A.

AU - Bertoni, Alain G.

AU - Soliman, Elsayed Z.

AU - Guo, Mengye

AU - Sibley, Christopher

AU - Chen, Yii Der I

AU - Rotter, Jerome I.

AU - Chen, Yi Chun

AU - Goff, David C.

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N2 - Background: The association between metabolic syndrome and electrocardiographic (ECG) abnormalities is not well established. Methods: ECG tracings of 6,765 men and women aged 45-84 years, free of clinical cardiovascular disease, from the Multi-Ethnic Study of Atherosclerosis were obtained (2000-2002) and classified as normal or having major or minor abnormalities. We evaluated the associations of metabolic syndrome and its components with ECG abnormalities, adjusting for age, ethnicity, and gender and testing for effect modification by ethnicity and gender. Results: The associations of metabolic syndrome, hypertension, and high triglycerides with ECG abnormalities varied significantly by gender. In males, metabolic syndrome and hypertension were significantly associated with major ECG abnormality [1.69 (1.33-2.13), and 2.22 (1.72-2.86), respectively] after adjusting for ethnicity and gender. Hypertension was also associated significantly with minor ECG abnormality in males after adjusting for age and ethnicity. In females, metabolic syndrome and hypertension were significantly associated with major [1.84 (1.44-2.37), and 1.68 (1.27-2.22), respectively] and minor [1.38 (1.19-1.59), and 1.53 (1.32-1.79), respectively] ECG abnormalities after adjusting for age and ethnicity. High triglycerides were only significantly associated with major ECG abnormality in females after adjusting for age and ethnicity. After adjusting for age, ethnicity, and gender, central obesity and high fasting blood glucose were significantly associated with major and minor ECG abnormalities, whereas low high-density lipoprotein cholesterol was significantly associated with major ECG abnormality only. Conclusions: Metabolic syndrome and its components are associated with major and/or minor ECG abnormalities. The relationship of metabolic syndrome, hypertension, and high triglycerides with ECG abnormalities varied according to gender.

AB - Background: The association between metabolic syndrome and electrocardiographic (ECG) abnormalities is not well established. Methods: ECG tracings of 6,765 men and women aged 45-84 years, free of clinical cardiovascular disease, from the Multi-Ethnic Study of Atherosclerosis were obtained (2000-2002) and classified as normal or having major or minor abnormalities. We evaluated the associations of metabolic syndrome and its components with ECG abnormalities, adjusting for age, ethnicity, and gender and testing for effect modification by ethnicity and gender. Results: The associations of metabolic syndrome, hypertension, and high triglycerides with ECG abnormalities varied significantly by gender. In males, metabolic syndrome and hypertension were significantly associated with major ECG abnormality [1.69 (1.33-2.13), and 2.22 (1.72-2.86), respectively] after adjusting for ethnicity and gender. Hypertension was also associated significantly with minor ECG abnormality in males after adjusting for age and ethnicity. In females, metabolic syndrome and hypertension were significantly associated with major [1.84 (1.44-2.37), and 1.68 (1.27-2.22), respectively] and minor [1.38 (1.19-1.59), and 1.53 (1.32-1.79), respectively] ECG abnormalities after adjusting for age and ethnicity. High triglycerides were only significantly associated with major ECG abnormality in females after adjusting for age and ethnicity. After adjusting for age, ethnicity, and gender, central obesity and high fasting blood glucose were significantly associated with major and minor ECG abnormalities, whereas low high-density lipoprotein cholesterol was significantly associated with major ECG abnormality only. Conclusions: Metabolic syndrome and its components are associated with major and/or minor ECG abnormalities. The relationship of metabolic syndrome, hypertension, and high triglycerides with ECG abnormalities varied according to gender.

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