Electroanatomic Substrate and Ablation Outcome for Suspected Epicardial Ventricular Tachycardia in Left Ventricular Nonischemic Cardiomyopathy

Oscar Cano, Mathew Hutchinson, David Lin, Fermin Garcia, Erica Zado, Rupa Bala, Michael Riley, Joshua Cooper, Sanjay Dixit, Edward Gerstenfeld, David Callans, Francis E. Marchlinski

Research output: Contribution to journalArticle

224 Citations (Scopus)

Abstract

Objectives: The aim of the study was to define the epicardial substrate and ablation outcome in patients with left ventricular nonischemic cardiomyopathy (NICM) and suspected epicardial ventricular tachycardia (VT). Background: Ventricular tachycardia in NICM often originates from the epicardium. Methods: Twenty-two patients with NICM underwent detailed endocardial and epicardial bipolar voltage maps and VT ablation for suspected epicardial VT. Eight patients with normal hearts and idiopathic VT served to define normal epicardial electrograms. Low-voltage regions were also assessed for wide (>80 ms), split, or late electrograms. Results: Normal epicardial bipolar voltage was identified as >1.0 mV on the basis of the reference population. Confluent low-voltage areas were present in 18 epicardial (82%) and 12 endocardial (54%) maps and were typically over basal lateral LV. In the 18 patients with epicardial VT on the basis of activation/pacemapping, the mean epicardial area was greater than the endocardial low-voltage area (55.3 ± 33.5 cm2 vs. 22.9 ± 32.4 cm2, p <0.01). Epicardial low-voltage areas showed 49.7% wide (>80 ms), split, and/or late electrograms rarely seen in the reference patients (2.3%). During follow-up of 18 ± 7 months, ablation resulted in VT elimination in 15 of 21 patients (71%) including 14 of 18 patients (78%) with epicardial VT. Conclusions: In patients with NICM and VT of epicardial origin, the substrate is characterized by areas of basal LV epicardial > endocardial bipolar low voltage. The electrograms in these areas are not only small (80 ms), split, and/or late, and help identify the substrate targeted for successful ablation.

Original languageEnglish (US)
Pages (from-to)799-808
Number of pages10
JournalJournal of the American College of Cardiology
Volume54
Issue number9
DOIs
StatePublished - Aug 25 2009
Externally publishedYes

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Ventricular Tachycardia
Cardiomyopathies
Pericardium

Keywords

  • electroanatomical mapping
  • nonischemic cardiomyopathy
  • ventricular tachycardia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Electroanatomic Substrate and Ablation Outcome for Suspected Epicardial Ventricular Tachycardia in Left Ventricular Nonischemic Cardiomyopathy. / Cano, Oscar; Hutchinson, Mathew; Lin, David; Garcia, Fermin; Zado, Erica; Bala, Rupa; Riley, Michael; Cooper, Joshua; Dixit, Sanjay; Gerstenfeld, Edward; Callans, David; Marchlinski, Francis E.

In: Journal of the American College of Cardiology, Vol. 54, No. 9, 25.08.2009, p. 799-808.

Research output: Contribution to journalArticle

Cano, O, Hutchinson, M, Lin, D, Garcia, F, Zado, E, Bala, R, Riley, M, Cooper, J, Dixit, S, Gerstenfeld, E, Callans, D & Marchlinski, FE 2009, 'Electroanatomic Substrate and Ablation Outcome for Suspected Epicardial Ventricular Tachycardia in Left Ventricular Nonischemic Cardiomyopathy', Journal of the American College of Cardiology, vol. 54, no. 9, pp. 799-808. https://doi.org/10.1016/j.jacc.2009.05.032
Cano, Oscar ; Hutchinson, Mathew ; Lin, David ; Garcia, Fermin ; Zado, Erica ; Bala, Rupa ; Riley, Michael ; Cooper, Joshua ; Dixit, Sanjay ; Gerstenfeld, Edward ; Callans, David ; Marchlinski, Francis E. / Electroanatomic Substrate and Ablation Outcome for Suspected Epicardial Ventricular Tachycardia in Left Ventricular Nonischemic Cardiomyopathy. In: Journal of the American College of Cardiology. 2009 ; Vol. 54, No. 9. pp. 799-808.
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abstract = "Objectives: The aim of the study was to define the epicardial substrate and ablation outcome in patients with left ventricular nonischemic cardiomyopathy (NICM) and suspected epicardial ventricular tachycardia (VT). Background: Ventricular tachycardia in NICM often originates from the epicardium. Methods: Twenty-two patients with NICM underwent detailed endocardial and epicardial bipolar voltage maps and VT ablation for suspected epicardial VT. Eight patients with normal hearts and idiopathic VT served to define normal epicardial electrograms. Low-voltage regions were also assessed for wide (>80 ms), split, or late electrograms. Results: Normal epicardial bipolar voltage was identified as >1.0 mV on the basis of the reference population. Confluent low-voltage areas were present in 18 epicardial (82{\%}) and 12 endocardial (54{\%}) maps and were typically over basal lateral LV. In the 18 patients with epicardial VT on the basis of activation/pacemapping, the mean epicardial area was greater than the endocardial low-voltage area (55.3 ± 33.5 cm2 vs. 22.9 ± 32.4 cm2, p <0.01). Epicardial low-voltage areas showed 49.7{\%} wide (>80 ms), split, and/or late electrograms rarely seen in the reference patients (2.3{\%}). During follow-up of 18 ± 7 months, ablation resulted in VT elimination in 15 of 21 patients (71{\%}) including 14 of 18 patients (78{\%}) with epicardial VT. Conclusions: In patients with NICM and VT of epicardial origin, the substrate is characterized by areas of basal LV epicardial > endocardial bipolar low voltage. The electrograms in these areas are not only small (80 ms), split, and/or late, and help identify the substrate targeted for successful ablation.",
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T1 - Electroanatomic Substrate and Ablation Outcome for Suspected Epicardial Ventricular Tachycardia in Left Ventricular Nonischemic Cardiomyopathy

AU - Cano, Oscar

AU - Hutchinson, Mathew

AU - Lin, David

AU - Garcia, Fermin

AU - Zado, Erica

AU - Bala, Rupa

AU - Riley, Michael

AU - Cooper, Joshua

AU - Dixit, Sanjay

AU - Gerstenfeld, Edward

AU - Callans, David

AU - Marchlinski, Francis E.

PY - 2009/8/25

Y1 - 2009/8/25

N2 - Objectives: The aim of the study was to define the epicardial substrate and ablation outcome in patients with left ventricular nonischemic cardiomyopathy (NICM) and suspected epicardial ventricular tachycardia (VT). Background: Ventricular tachycardia in NICM often originates from the epicardium. Methods: Twenty-two patients with NICM underwent detailed endocardial and epicardial bipolar voltage maps and VT ablation for suspected epicardial VT. Eight patients with normal hearts and idiopathic VT served to define normal epicardial electrograms. Low-voltage regions were also assessed for wide (>80 ms), split, or late electrograms. Results: Normal epicardial bipolar voltage was identified as >1.0 mV on the basis of the reference population. Confluent low-voltage areas were present in 18 epicardial (82%) and 12 endocardial (54%) maps and were typically over basal lateral LV. In the 18 patients with epicardial VT on the basis of activation/pacemapping, the mean epicardial area was greater than the endocardial low-voltage area (55.3 ± 33.5 cm2 vs. 22.9 ± 32.4 cm2, p <0.01). Epicardial low-voltage areas showed 49.7% wide (>80 ms), split, and/or late electrograms rarely seen in the reference patients (2.3%). During follow-up of 18 ± 7 months, ablation resulted in VT elimination in 15 of 21 patients (71%) including 14 of 18 patients (78%) with epicardial VT. Conclusions: In patients with NICM and VT of epicardial origin, the substrate is characterized by areas of basal LV epicardial > endocardial bipolar low voltage. The electrograms in these areas are not only small (80 ms), split, and/or late, and help identify the substrate targeted for successful ablation.

AB - Objectives: The aim of the study was to define the epicardial substrate and ablation outcome in patients with left ventricular nonischemic cardiomyopathy (NICM) and suspected epicardial ventricular tachycardia (VT). Background: Ventricular tachycardia in NICM often originates from the epicardium. Methods: Twenty-two patients with NICM underwent detailed endocardial and epicardial bipolar voltage maps and VT ablation for suspected epicardial VT. Eight patients with normal hearts and idiopathic VT served to define normal epicardial electrograms. Low-voltage regions were also assessed for wide (>80 ms), split, or late electrograms. Results: Normal epicardial bipolar voltage was identified as >1.0 mV on the basis of the reference population. Confluent low-voltage areas were present in 18 epicardial (82%) and 12 endocardial (54%) maps and were typically over basal lateral LV. In the 18 patients with epicardial VT on the basis of activation/pacemapping, the mean epicardial area was greater than the endocardial low-voltage area (55.3 ± 33.5 cm2 vs. 22.9 ± 32.4 cm2, p <0.01). Epicardial low-voltage areas showed 49.7% wide (>80 ms), split, and/or late electrograms rarely seen in the reference patients (2.3%). During follow-up of 18 ± 7 months, ablation resulted in VT elimination in 15 of 21 patients (71%) including 14 of 18 patients (78%) with epicardial VT. Conclusions: In patients with NICM and VT of epicardial origin, the substrate is characterized by areas of basal LV epicardial > endocardial bipolar low voltage. The electrograms in these areas are not only small (80 ms), split, and/or late, and help identify the substrate targeted for successful ablation.

KW - electroanatomical mapping

KW - nonischemic cardiomyopathy

KW - ventricular tachycardia

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