Elastosis of the lamina cribrosa in glaucomatous optic neuropathy

Janethe D O Pena, Peter A. Netland, Ivonne Vidal, David Dorr, Adam Rasky, M. Rosario Hernandez

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

The purpose of this study was to determine whether elastotic degeneration of the elastin component of the lamina cribrosa occurs in optic neuropathy associated with different types of glaucoma. Human optic nerve heads with primary open-angle, neovascular, chronic angle closure and pseudoexfoliation glaucoma, and with varying duration of disease were compared with age-matched normal eyes, using electron microscopy and immunogold labeling of elastin. The percent area occupied by immunogold labeled elastin material was determined using a digital image analysis system. In all eyes with a history of glaucoma, elastosis was found in the lamina cribrosa and there was a significantly greater percentage of area occupied by elastin compared with age-matched control eyes (P <0.0001). Among the glaucomatous eyes, pseudoexfoliation glaucoma had the largest area of elastosis, followed by primary open-angle and secondary glaucoma (neovascular and chronic angle closure). In all glaucoma samples, large, confluent elastin aggregates of irregular and varied shapes (elastosis) were observed in the lamina cribrosa and insertion region. These results demonstrate that glaucomatous optic neuropathy is associated with elastosis of the lamina cribrosa, which may contribute to the changes in compliance of the optic nerve heads of glaucomatous eyes.

Original languageEnglish (US)
Pages (from-to)517-524
Number of pages8
JournalExperimental Eye Research
Volume67
Issue number5
DOIs
StatePublished - Nov 1998
Externally publishedYes

Fingerprint

Optic Nerve Diseases
Elastin
Glaucoma
Optic Disk
Angle Closure Glaucoma
Compliance
Electron Microscopy

Keywords

  • Elastin
  • Electron microscopy
  • Glaucoma
  • Lamina cribrosa
  • Morphometry

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

Pena, J. D. O., Netland, P. A., Vidal, I., Dorr, D., Rasky, A., & Hernandez, M. R. (1998). Elastosis of the lamina cribrosa in glaucomatous optic neuropathy. Experimental Eye Research, 67(5), 517-524. https://doi.org/10.1006/exer.1998.0539

Elastosis of the lamina cribrosa in glaucomatous optic neuropathy. / Pena, Janethe D O; Netland, Peter A.; Vidal, Ivonne; Dorr, David; Rasky, Adam; Hernandez, M. Rosario.

In: Experimental Eye Research, Vol. 67, No. 5, 11.1998, p. 517-524.

Research output: Contribution to journalArticle

Pena, JDO, Netland, PA, Vidal, I, Dorr, D, Rasky, A & Hernandez, MR 1998, 'Elastosis of the lamina cribrosa in glaucomatous optic neuropathy', Experimental Eye Research, vol. 67, no. 5, pp. 517-524. https://doi.org/10.1006/exer.1998.0539
Pena, Janethe D O ; Netland, Peter A. ; Vidal, Ivonne ; Dorr, David ; Rasky, Adam ; Hernandez, M. Rosario. / Elastosis of the lamina cribrosa in glaucomatous optic neuropathy. In: Experimental Eye Research. 1998 ; Vol. 67, No. 5. pp. 517-524.
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