Elastin as a potential biomaterial

Monica Hinds, Jenny Strooband, Mason Kwong, Dhruv Dayal, Halina BrantZawadzki, Rui Quing Qian, Kenton Gregory

Research output: Contribution to journalConference article

Abstract

Porcine vessels, including aortas and carotids, were digested by boiling them in sodium hydroxide until only elastin remained. Amino acid analysis confirmed the extraction of pure porcine elastin. SEM analysis indicated the fibrous structure. The elastin was characterized with axial and circumferential tensile tests to determine yield strengths, elastic moduli, and expansion ratios. Subdermal implant experiments conducted in BALB/C mice demonstrated both the lack of antigenicity and host response for cross species implantation and the ability to prevent its calcification. Vascular implantations revealed the non-thrombogenic characteristic of elastin.

Original languageEnglish (US)
Pages (from-to)S-20
JournalAnnals of Biomedical Engineering
Volume28
Issue numberSUPPL. 1
StatePublished - Dec 1 2000
Event2000 Annual Fall Meeting of the Biomedical Engineering Society - Washington, WA, USA
Duration: Oct 12 2000Oct 14 2000

ASJC Scopus subject areas

  • Biomedical Engineering

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  • Cite this

    Hinds, M., Strooband, J., Kwong, M., Dayal, D., BrantZawadzki, H., Qian, R. Q., & Gregory, K. (2000). Elastin as a potential biomaterial. Annals of Biomedical Engineering, 28(SUPPL. 1), S-20.