ELAM-1 is an adhesion molecule for skin-homing T cells

Louis J. Picker, Takashi K. Kishimoto, C. Wayne Smith, R. Aaron Warnock, Eugene C. Butcher

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Abstract

ENDOTHELIAL cell leukocyte adhesion molecule-1 (ELAM-1) has been described as an inducible endothelial cell-adhesion molecule for neutrophils, and is believed to have a key role in the extravasation of these cells at sites of acute inflammation1-3. Here we report that ELAM-1-transfected COS cells also bind a unique skin-associated subset of circulating memory T cells defined by the expression of the cutaneous lymphocyte-associated antigen4,5. T cells expressing this antigen bind at least as well as neutrophils to expressed ELAM-1, whereas other lymphocytes in the peripheral blood bind poorly, or not at all. Immunohistological survey of chronically inflamed tissue specimens revealed that vascular expression of ELAM-1 occurs at cutaneous sites in preference to noncutaneous sites. We conclude that at sites of chronic inflammation, ELAM-1 may function as a skin vascular addressin, a tissue-selective endothelial cell-adhesion molecule for skin-homing memory T lymphocytes.

Original languageEnglish (US)
Pages (from-to)796-799
Number of pages4
JournalNature
Volume349
Issue number6312
DOIs
StatePublished - Jan 1 1991

ASJC Scopus subject areas

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    Picker, L. J., Kishimoto, T. K., Smith, C. W., Warnock, R. A., & Butcher, E. C. (1991). ELAM-1 is an adhesion molecule for skin-homing T cells. Nature, 349(6312), 796-799. https://doi.org/10.1038/349796a0