ELAM-1 is an adhesion molecule for skin-homing T cells

Louis Picker, Takashi K. Kishimoto, C. Wayne Smith, R. Aaron Warnock, Eugene C. Butcher

Research output: Contribution to journalArticle

693 Citations (Scopus)

Abstract

ENDOTHELIAL cell leukocyte adhesion molecule-1 (ELAM-1) has been described as an inducible endothelial cell-adhesion molecule for neutrophils, and is believed to have a key role in the extravasation of these cells at sites of acute inflammation1-3. Here we report that ELAM-1-transfected COS cells also bind a unique skin-associated subset of circulating memory T cells defined by the expression of the cutaneous lymphocyte-associated antigen4,5. T cells expressing this antigen bind at least as well as neutrophils to expressed ELAM-1, whereas other lymphocytes in the peripheral blood bind poorly, or not at all. Immunohistological survey of chronically inflamed tissue specimens revealed that vascular expression of ELAM-1 occurs at cutaneous sites in preference to noncutaneous sites. We conclude that at sites of chronic inflammation, ELAM-1 may function as a skin vascular addressin, a tissue-selective endothelial cell-adhesion molecule for skin-homing memory T lymphocytes.

Original languageEnglish (US)
Pages (from-to)796-799
Number of pages4
JournalNature
Volume349
Issue number6312
StatePublished - Feb 28 1991

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Cell Adhesion Molecules
T-Lymphocytes
Skin
Neutrophils
Endothelial Cells
Lymphocytes
COS Cells
Blood Vessels
Inflammation

ASJC Scopus subject areas

  • General

Cite this

Picker, L., Kishimoto, T. K., Smith, C. W., Warnock, R. A., & Butcher, E. C. (1991). ELAM-1 is an adhesion molecule for skin-homing T cells. Nature, 349(6312), 796-799.

ELAM-1 is an adhesion molecule for skin-homing T cells. / Picker, Louis; Kishimoto, Takashi K.; Smith, C. Wayne; Warnock, R. Aaron; Butcher, Eugene C.

In: Nature, Vol. 349, No. 6312, 28.02.1991, p. 796-799.

Research output: Contribution to journalArticle

Picker, L, Kishimoto, TK, Smith, CW, Warnock, RA & Butcher, EC 1991, 'ELAM-1 is an adhesion molecule for skin-homing T cells', Nature, vol. 349, no. 6312, pp. 796-799.
Picker L, Kishimoto TK, Smith CW, Warnock RA, Butcher EC. ELAM-1 is an adhesion molecule for skin-homing T cells. Nature. 1991 Feb 28;349(6312):796-799.
Picker, Louis ; Kishimoto, Takashi K. ; Smith, C. Wayne ; Warnock, R. Aaron ; Butcher, Eugene C. / ELAM-1 is an adhesion molecule for skin-homing T cells. In: Nature. 1991 ; Vol. 349, No. 6312. pp. 796-799.
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