Efflux of amino acid neurotransmitters from brain slices

Role of membrane transport

John Hammerstad, R. W P Cutler

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

When the efflux of 3H-GABA and 14C-glutamate was maximally stimulated by exchange diffusion with unlabeled amino acids, electrical stimulation was incapable of producing further release. This suggests carrier mediated membrane transport may be a limiting factor in the release of amino acid neurotransmitters from brain slices.

Original languageEnglish (US)
Pages (from-to)118-121
Number of pages4
JournalEuropean Journal of Pharmacology
Volume20
Issue number1
DOIs
StatePublished - 1972
Externally publishedYes

Fingerprint

Neurotransmitter Agents
Amino Acids
Membranes
Brain
gamma-Aminobutyric Acid
Electric Stimulation
Glutamic Acid

Keywords

  • Amino acid neurotransmitter release
  • Carrier mediated transport

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Efflux of amino acid neurotransmitters from brain slices : Role of membrane transport. / Hammerstad, John; Cutler, R. W P.

In: European Journal of Pharmacology, Vol. 20, No. 1, 1972, p. 118-121.

Research output: Contribution to journalArticle

@article{6a776d4f545b4ca78d5c7599dafabac9,
title = "Efflux of amino acid neurotransmitters from brain slices: Role of membrane transport",
abstract = "When the efflux of 3H-GABA and 14C-glutamate was maximally stimulated by exchange diffusion with unlabeled amino acids, electrical stimulation was incapable of producing further release. This suggests carrier mediated membrane transport may be a limiting factor in the release of amino acid neurotransmitters from brain slices.",
keywords = "Amino acid neurotransmitter release, Carrier mediated transport",
author = "John Hammerstad and Cutler, {R. W P}",
year = "1972",
doi = "10.1016/0014-2999(72)90225-7",
language = "English (US)",
volume = "20",
pages = "118--121",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Efflux of amino acid neurotransmitters from brain slices

T2 - Role of membrane transport

AU - Hammerstad, John

AU - Cutler, R. W P

PY - 1972

Y1 - 1972

N2 - When the efflux of 3H-GABA and 14C-glutamate was maximally stimulated by exchange diffusion with unlabeled amino acids, electrical stimulation was incapable of producing further release. This suggests carrier mediated membrane transport may be a limiting factor in the release of amino acid neurotransmitters from brain slices.

AB - When the efflux of 3H-GABA and 14C-glutamate was maximally stimulated by exchange diffusion with unlabeled amino acids, electrical stimulation was incapable of producing further release. This suggests carrier mediated membrane transport may be a limiting factor in the release of amino acid neurotransmitters from brain slices.

KW - Amino acid neurotransmitter release

KW - Carrier mediated transport

UR - http://www.scopus.com/inward/record.url?scp=0015406881&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015406881&partnerID=8YFLogxK

U2 - 10.1016/0014-2999(72)90225-7

DO - 10.1016/0014-2999(72)90225-7

M3 - Article

VL - 20

SP - 118

EP - 121

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 1

ER -