Efficacy of oral fecal bacteriotherapy in rhesus macaques (Macaca mulatta) with chronic diarrhea

Christie E. Ferrecchia, Theodore Hobbs

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Abstract

    Chronic diarrhea remains the principal burden in providing health care for nonhuman primates in biomedical research facilities. Although the exact etiology continues to puzzle nonhuman primate clinicians, recent research in humans has shown that restoring the indigenous microbial diversity may be successful in resolving cases of chronic diarrhea when other treatment modalities have failed. The process of restoring this microbial balance, known as fecal bacteriotherapy, uses the complete flora from a normal donor as a therapeutic probiotic mixture. In the current study, Indian-origin rhesus macaques were randomized into treatment (n = 7) and control (n = 6) groups to determine whether orally administered fecal bacteriotherapy would reduce the overall incidence of chronic diarrhea during a 60-d follow-up period in the treatment group compared with control macaques, which received a placebo. Although the treatment effect, determined by comparing the baseline fecal scores of the treatment and control groups, did not reach statistical significance, preprocedure and postprocedure fecal scores in the treatment group differed significantly. These findings are encouraging, and we hope that our study will motivate larger studies evaluating the use of fecal bacteriotherapy in nonhuman primates.

    Original languageEnglish (US)
    Pages (from-to)71-75
    Number of pages5
    JournalComparative Medicine
    Volume63
    Issue number1
    StatePublished - Feb 2013

    Fingerprint

    Macaca mulatta
    Diarrhea
    diarrhea
    mouth
    Primates
    research facilities
    biomedical research
    Health care
    Macaca
    health services
    probiotics
    placebos
    etiology
    Therapeutics
    flora
    incidence
    therapeutics
    Probiotics
    Biomedical Research
    Placebos

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)
    • veterinary(all)

    Cite this

    Efficacy of oral fecal bacteriotherapy in rhesus macaques (Macaca mulatta) with chronic diarrhea. / Ferrecchia, Christie E.; Hobbs, Theodore.

    In: Comparative Medicine, Vol. 63, No. 1, 02.2013, p. 71-75.

    Research output: Contribution to journalArticle

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