Efficacy of LY233053, a competitive glutamate antagonist, in experimental central nervous system ischemia

K. P. Madden, Wayne Clark, A. Kochhar, J. A. Zivin

Research output: Contribution to journalArticle

16 Scopus citations


Antagonists of excitatory amino acids appear to serve a neuroprotective role during ischemic conditions in a variety of in vivo and in vitro models. The usefulness of such agents in the clinical setting, however, may be limited by poor central nervous system (CNS) entry and intolerable side effects. The authors report high efficacy in reducing neurological damage and relatively limited side effects of LY233053, a novel competitive glutamate antagonist, in two models of experimental CNS ischemia in the rabbit.

Original languageEnglish (US)
Pages (from-to)106-110
Number of pages5
JournalJournal of Neurosurgery
Issue number1
StatePublished - 1992
Externally publishedYes



  • amino acid receptor
  • glutamate antagonist
  • ischemia
  • rabbit

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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