Efficacy and tolerability of pharmacotherapies to aid smoking cessation in adolescents

Steffani Bailey, Erin E. Crew, Emily C. Riske, Seth Ammerman, Thomas N. Robinson, Joel D. Killen

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Adolescent smoking remains a public health problem. Despite concerns regarding adolescent nicotine dependence, few well-designed smoking cessation studies have been conducted with teen smokers. This is particularly true regarding pharmacologic treatments for nicotine dependence. Currently, pharmacologic aids are not recommended for treating adolescent nicotine dependence, as efficacy has not been shown in this population.This review includes studies that have examined the efficacy of pharmacotherapy for smoking abstinence andor reduction in cigarette consumption among adolescent smokers who want to quit smoking, laboratory-based adolescent studies that have examined the efficacy of these medications in reducing cravings andor withdrawal symptoms, andor studies that have assessed the tolerability of medications for smoking cessation in adolescent smokers. It provides information on the pharmacologic action of each medication, the efficacy of each medication for adolescent smoking cessation, the tolerability of each medication based on reported adverse events, and compliance with the medication protocols. Thirteen relevant articles were identified and included in the review. Nicotine patch (NP), nicotine gum, nicotine nasal spray, bupropion, and varenicline have been studied in adolescent smokers. The adverse events reported in the studies on pharmacology for adolescent smoking suggest that the side effect profiles for nicotine replacement therapy, bupropion, and varenicline are similar to those reported in adult studies. There is some evidence of efficacy of NP and bupropion at the end of treatment (efficacy of varenicline has not been assessed), but none of the medications included in this review were efficacious in promoting long-term smoking cessation among adolescent smokers. It is noted that many of the study protocols did not follow the recommended dose or length of pharmacotherapy for adults, rendering it difficult to determine the true efficacy of medication for adolescent smoking cessation. Future efficacy studies are warranted before recommending pharmacotherapy for adolescent smoking cessation.

Original languageEnglish (US)
Pages (from-to)91-108
Number of pages18
JournalPediatric Drugs
Volume14
Issue number2
DOIs
StatePublished - 2012

Fingerprint

Smoking Cessation
Drug Therapy
Tobacco Use Cessation Products
Bupropion
Tobacco Use Disorder
Smoking
Nicotine
Pharmacologic Actions
Substance Withdrawal Syndrome
Medication Adherence
Tobacco Products
Public Health
Pharmacology

Keywords

  • Adolescents
  • Bupropion
  • Nicotine-replacement-therapy
  • Smoking-cessation- therapies
  • Smoking-withdrawal
  • Varenicline.

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pharmacology (medical)

Cite this

Efficacy and tolerability of pharmacotherapies to aid smoking cessation in adolescents. / Bailey, Steffani; Crew, Erin E.; Riske, Emily C.; Ammerman, Seth; Robinson, Thomas N.; Killen, Joel D.

In: Pediatric Drugs, Vol. 14, No. 2, 2012, p. 91-108.

Research output: Contribution to journalArticle

Bailey, Steffani ; Crew, Erin E. ; Riske, Emily C. ; Ammerman, Seth ; Robinson, Thomas N. ; Killen, Joel D. / Efficacy and tolerability of pharmacotherapies to aid smoking cessation in adolescents. In: Pediatric Drugs. 2012 ; Vol. 14, No. 2. pp. 91-108.
@article{c1225547f9174f0f8a09b18dd47271b8,
title = "Efficacy and tolerability of pharmacotherapies to aid smoking cessation in adolescents",
abstract = "Adolescent smoking remains a public health problem. Despite concerns regarding adolescent nicotine dependence, few well-designed smoking cessation studies have been conducted with teen smokers. This is particularly true regarding pharmacologic treatments for nicotine dependence. Currently, pharmacologic aids are not recommended for treating adolescent nicotine dependence, as efficacy has not been shown in this population.This review includes studies that have examined the efficacy of pharmacotherapy for smoking abstinence andor reduction in cigarette consumption among adolescent smokers who want to quit smoking, laboratory-based adolescent studies that have examined the efficacy of these medications in reducing cravings andor withdrawal symptoms, andor studies that have assessed the tolerability of medications for smoking cessation in adolescent smokers. It provides information on the pharmacologic action of each medication, the efficacy of each medication for adolescent smoking cessation, the tolerability of each medication based on reported adverse events, and compliance with the medication protocols. Thirteen relevant articles were identified and included in the review. Nicotine patch (NP), nicotine gum, nicotine nasal spray, bupropion, and varenicline have been studied in adolescent smokers. The adverse events reported in the studies on pharmacology for adolescent smoking suggest that the side effect profiles for nicotine replacement therapy, bupropion, and varenicline are similar to those reported in adult studies. There is some evidence of efficacy of NP and bupropion at the end of treatment (efficacy of varenicline has not been assessed), but none of the medications included in this review were efficacious in promoting long-term smoking cessation among adolescent smokers. It is noted that many of the study protocols did not follow the recommended dose or length of pharmacotherapy for adults, rendering it difficult to determine the true efficacy of medication for adolescent smoking cessation. Future efficacy studies are warranted before recommending pharmacotherapy for adolescent smoking cessation.",
keywords = "Adolescents, Bupropion, Nicotine-replacement-therapy, Smoking-cessation- therapies, Smoking-withdrawal, Varenicline.",
author = "Steffani Bailey and Crew, {Erin E.} and Riske, {Emily C.} and Seth Ammerman and Robinson, {Thomas N.} and Killen, {Joel D.}",
year = "2012",
doi = "10.2165/11594370-000000000-00000",
language = "English (US)",
volume = "14",
pages = "91--108",
journal = "Paediatric Drugs",
issn = "1174-5878",
publisher = "Adis International Ltd",
number = "2",

}

TY - JOUR

T1 - Efficacy and tolerability of pharmacotherapies to aid smoking cessation in adolescents

AU - Bailey, Steffani

AU - Crew, Erin E.

AU - Riske, Emily C.

AU - Ammerman, Seth

AU - Robinson, Thomas N.

AU - Killen, Joel D.

PY - 2012

Y1 - 2012

N2 - Adolescent smoking remains a public health problem. Despite concerns regarding adolescent nicotine dependence, few well-designed smoking cessation studies have been conducted with teen smokers. This is particularly true regarding pharmacologic treatments for nicotine dependence. Currently, pharmacologic aids are not recommended for treating adolescent nicotine dependence, as efficacy has not been shown in this population.This review includes studies that have examined the efficacy of pharmacotherapy for smoking abstinence andor reduction in cigarette consumption among adolescent smokers who want to quit smoking, laboratory-based adolescent studies that have examined the efficacy of these medications in reducing cravings andor withdrawal symptoms, andor studies that have assessed the tolerability of medications for smoking cessation in adolescent smokers. It provides information on the pharmacologic action of each medication, the efficacy of each medication for adolescent smoking cessation, the tolerability of each medication based on reported adverse events, and compliance with the medication protocols. Thirteen relevant articles were identified and included in the review. Nicotine patch (NP), nicotine gum, nicotine nasal spray, bupropion, and varenicline have been studied in adolescent smokers. The adverse events reported in the studies on pharmacology for adolescent smoking suggest that the side effect profiles for nicotine replacement therapy, bupropion, and varenicline are similar to those reported in adult studies. There is some evidence of efficacy of NP and bupropion at the end of treatment (efficacy of varenicline has not been assessed), but none of the medications included in this review were efficacious in promoting long-term smoking cessation among adolescent smokers. It is noted that many of the study protocols did not follow the recommended dose or length of pharmacotherapy for adults, rendering it difficult to determine the true efficacy of medication for adolescent smoking cessation. Future efficacy studies are warranted before recommending pharmacotherapy for adolescent smoking cessation.

AB - Adolescent smoking remains a public health problem. Despite concerns regarding adolescent nicotine dependence, few well-designed smoking cessation studies have been conducted with teen smokers. This is particularly true regarding pharmacologic treatments for nicotine dependence. Currently, pharmacologic aids are not recommended for treating adolescent nicotine dependence, as efficacy has not been shown in this population.This review includes studies that have examined the efficacy of pharmacotherapy for smoking abstinence andor reduction in cigarette consumption among adolescent smokers who want to quit smoking, laboratory-based adolescent studies that have examined the efficacy of these medications in reducing cravings andor withdrawal symptoms, andor studies that have assessed the tolerability of medications for smoking cessation in adolescent smokers. It provides information on the pharmacologic action of each medication, the efficacy of each medication for adolescent smoking cessation, the tolerability of each medication based on reported adverse events, and compliance with the medication protocols. Thirteen relevant articles were identified and included in the review. Nicotine patch (NP), nicotine gum, nicotine nasal spray, bupropion, and varenicline have been studied in adolescent smokers. The adverse events reported in the studies on pharmacology for adolescent smoking suggest that the side effect profiles for nicotine replacement therapy, bupropion, and varenicline are similar to those reported in adult studies. There is some evidence of efficacy of NP and bupropion at the end of treatment (efficacy of varenicline has not been assessed), but none of the medications included in this review were efficacious in promoting long-term smoking cessation among adolescent smokers. It is noted that many of the study protocols did not follow the recommended dose or length of pharmacotherapy for adults, rendering it difficult to determine the true efficacy of medication for adolescent smoking cessation. Future efficacy studies are warranted before recommending pharmacotherapy for adolescent smoking cessation.

KW - Adolescents

KW - Bupropion

KW - Nicotine-replacement-therapy

KW - Smoking-cessation- therapies

KW - Smoking-withdrawal

KW - Varenicline.

UR - http://www.scopus.com/inward/record.url?scp=84857249934&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84857249934&partnerID=8YFLogxK

U2 - 10.2165/11594370-000000000-00000

DO - 10.2165/11594370-000000000-00000

M3 - Article

VL - 14

SP - 91

EP - 108

JO - Paediatric Drugs

JF - Paediatric Drugs

SN - 1174-5878

IS - 2

ER -