Effects of vecuronium-induced histamine N-methyltransferase inhibition on cutaneous responses to histamine

J. H. Levy, David Adelson

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

All muscle relaxants inhibit histamine N-methyltransferase in vitro, but vecuronium, a steroid-derived muscle relaxant, is the most potent inhibitor. It has been suggested that administration of vecuronium prior to giving a drug that releases histamine may exaggerate the hemodynamic or vascular effects. Volunteers were injected intradermally with 5×10-4M concentrations of histamine, and the combination of vecuronium and histamine, to evaluate the in vivo significance. Vecuronium did not alter the measured wheal and flare responses to injected histamine at 5, 15, 30, 40, 50 and 60 mins. There is no evidence that inhibition of histamine N-methyltransferase in vivo will alter the vascular effects of histamine.

Original languageEnglish (US)
JournalAgents and Actions
Volume36
Issue number2 Supplement
DOIs
StatePublished - Jun 1992
Externally publishedYes

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Histamine N-Methyltransferase
Vecuronium Bromide
Histamine
Skin
Blood Vessels
Muscle
Muscles
Hemodynamics
Volunteers
Steroids
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

Cite this

Effects of vecuronium-induced histamine N-methyltransferase inhibition on cutaneous responses to histamine. / Levy, J. H.; Adelson, David.

In: Agents and Actions, Vol. 36, No. 2 Supplement, 06.1992.

Research output: Contribution to journalArticle

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