Effects of vaccination with T cell receptor peptides

Epitope switching to a possible disease-protective determinant of myelin basic protein that is cross-reactive with a TCR BV peptide

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4 Citations (Scopus)

Abstract

Immunization of Lewis rats with guinea-pig myelin basic protein (Gp- MBP) induced T cell responses to primary and secondary encephalitogenic determinants, as well as to a third non-encephalitogenic epitope, residues 55-69. This sequence is of interest due to its protective activity against experimental autoimmune encephalomyelitis. Protection involved induction of MBP-55-69-specific T cells expressing cross-reactive TCR BV8S6 genes that activated regulatory T cells specific for TCR BV8S2 determinants expressed on encephalitogenic T cells. We here present and discuss new evidence suggesting a possible immunological cross-reactivity between the protective Gp-MBP-55- 69 peptide and the regulatory BV8S2-39-59 peptide. This cross-reactivity, which may also occur between the human MBP-55-74 peptide and the BV12S2-38- 58 sequence, has potentially important implications for human diseases such as multiple sclerosis.

Original languageEnglish (US)
Pages (from-to)83-90
Number of pages8
JournalImmunology and Cell Biology
Volume76
Issue number1
DOIs
StatePublished - 1998

Fingerprint

Myelin Basic Protein
T-cells
T-Cell Antigen Receptor
Epitopes
Vaccination
T-Lymphocytes
Peptides
Autoimmune Experimental Encephalomyelitis
Regulatory T-Lymphocytes
Immunization
Multiple Sclerosis
Guinea Pigs
Rats
Genes

Keywords

  • Cross-reactivity
  • Experimental autoimmune encephalomyelitis
  • Multiple sclerosis
  • Myelin basic protein
  • Regulatory T cells
  • T cell receptor peptides

ASJC Scopus subject areas

  • Immunology
  • Clinical Biochemistry
  • Cell Biology

Cite this

@article{be13863d8a4241f39a77ac5289be076f,
title = "Effects of vaccination with T cell receptor peptides: Epitope switching to a possible disease-protective determinant of myelin basic protein that is cross-reactive with a TCR BV peptide",
abstract = "Immunization of Lewis rats with guinea-pig myelin basic protein (Gp- MBP) induced T cell responses to primary and secondary encephalitogenic determinants, as well as to a third non-encephalitogenic epitope, residues 55-69. This sequence is of interest due to its protective activity against experimental autoimmune encephalomyelitis. Protection involved induction of MBP-55-69-specific T cells expressing cross-reactive TCR BV8S6 genes that activated regulatory T cells specific for TCR BV8S2 determinants expressed on encephalitogenic T cells. We here present and discuss new evidence suggesting a possible immunological cross-reactivity between the protective Gp-MBP-55- 69 peptide and the regulatory BV8S2-39-59 peptide. This cross-reactivity, which may also occur between the human MBP-55-74 peptide and the BV12S2-38- 58 sequence, has potentially important implications for human diseases such as multiple sclerosis.",
keywords = "Cross-reactivity, Experimental autoimmune encephalomyelitis, Multiple sclerosis, Myelin basic protein, Regulatory T cells, T cell receptor peptides",
author = "Arthur Vandenbark and Chou, {Yuan K.} and Ruth Whitham and Dennis Bourdette and Halina Offner",
year = "1998",
doi = "10.1046/j.1440-1711.1998.00720.x",
language = "English (US)",
volume = "76",
pages = "83--90",
journal = "Immunology and Cell Biology",
issn = "0818-9641",
publisher = "Nature Publishing Group",
number = "1",

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TY - JOUR

T1 - Effects of vaccination with T cell receptor peptides

T2 - Epitope switching to a possible disease-protective determinant of myelin basic protein that is cross-reactive with a TCR BV peptide

AU - Vandenbark, Arthur

AU - Chou, Yuan K.

AU - Whitham, Ruth

AU - Bourdette, Dennis

AU - Offner, Halina

PY - 1998

Y1 - 1998

N2 - Immunization of Lewis rats with guinea-pig myelin basic protein (Gp- MBP) induced T cell responses to primary and secondary encephalitogenic determinants, as well as to a third non-encephalitogenic epitope, residues 55-69. This sequence is of interest due to its protective activity against experimental autoimmune encephalomyelitis. Protection involved induction of MBP-55-69-specific T cells expressing cross-reactive TCR BV8S6 genes that activated regulatory T cells specific for TCR BV8S2 determinants expressed on encephalitogenic T cells. We here present and discuss new evidence suggesting a possible immunological cross-reactivity between the protective Gp-MBP-55- 69 peptide and the regulatory BV8S2-39-59 peptide. This cross-reactivity, which may also occur between the human MBP-55-74 peptide and the BV12S2-38- 58 sequence, has potentially important implications for human diseases such as multiple sclerosis.

AB - Immunization of Lewis rats with guinea-pig myelin basic protein (Gp- MBP) induced T cell responses to primary and secondary encephalitogenic determinants, as well as to a third non-encephalitogenic epitope, residues 55-69. This sequence is of interest due to its protective activity against experimental autoimmune encephalomyelitis. Protection involved induction of MBP-55-69-specific T cells expressing cross-reactive TCR BV8S6 genes that activated regulatory T cells specific for TCR BV8S2 determinants expressed on encephalitogenic T cells. We here present and discuss new evidence suggesting a possible immunological cross-reactivity between the protective Gp-MBP-55- 69 peptide and the regulatory BV8S2-39-59 peptide. This cross-reactivity, which may also occur between the human MBP-55-74 peptide and the BV12S2-38- 58 sequence, has potentially important implications for human diseases such as multiple sclerosis.

KW - Cross-reactivity

KW - Experimental autoimmune encephalomyelitis

KW - Multiple sclerosis

KW - Myelin basic protein

KW - Regulatory T cells

KW - T cell receptor peptides

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U2 - 10.1046/j.1440-1711.1998.00720.x

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