TY - JOUR
T1 - Effects of vaccination with T cell receptor peptides
T2 - Epitope switching to a possible disease-protective determinant of myelin basic protein that is cross-reactive with a TCR BV peptide
AU - Vandenbark, Arthur A.
AU - Chou, Yuan K.
AU - Whitham, Ruth
AU - Bourdette, Dennis N.
AU - Offner, Halina
PY - 1998
Y1 - 1998
N2 - Immunization of Lewis rats with guinea-pig myelin basic protein (Gp- MBP) induced T cell responses to primary and secondary encephalitogenic determinants, as well as to a third non-encephalitogenic epitope, residues 55-69. This sequence is of interest due to its protective activity against experimental autoimmune encephalomyelitis. Protection involved induction of MBP-55-69-specific T cells expressing cross-reactive TCR BV8S6 genes that activated regulatory T cells specific for TCR BV8S2 determinants expressed on encephalitogenic T cells. We here present and discuss new evidence suggesting a possible immunological cross-reactivity between the protective Gp-MBP-55- 69 peptide and the regulatory BV8S2-39-59 peptide. This cross-reactivity, which may also occur between the human MBP-55-74 peptide and the BV12S2-38- 58 sequence, has potentially important implications for human diseases such as multiple sclerosis.
AB - Immunization of Lewis rats with guinea-pig myelin basic protein (Gp- MBP) induced T cell responses to primary and secondary encephalitogenic determinants, as well as to a third non-encephalitogenic epitope, residues 55-69. This sequence is of interest due to its protective activity against experimental autoimmune encephalomyelitis. Protection involved induction of MBP-55-69-specific T cells expressing cross-reactive TCR BV8S6 genes that activated regulatory T cells specific for TCR BV8S2 determinants expressed on encephalitogenic T cells. We here present and discuss new evidence suggesting a possible immunological cross-reactivity between the protective Gp-MBP-55- 69 peptide and the regulatory BV8S2-39-59 peptide. This cross-reactivity, which may also occur between the human MBP-55-74 peptide and the BV12S2-38- 58 sequence, has potentially important implications for human diseases such as multiple sclerosis.
KW - Cross-reactivity
KW - Experimental autoimmune encephalomyelitis
KW - Multiple sclerosis
KW - Myelin basic protein
KW - Regulatory T cells
KW - T cell receptor peptides
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U2 - 10.1046/j.1440-1711.1998.00720.x
DO - 10.1046/j.1440-1711.1998.00720.x
M3 - Article
C2 - 9553780
AN - SCOPUS:0031901256
SN - 0818-9641
VL - 76
SP - 83
EP - 90
JO - Immunology and Cell Biology
JF - Immunology and Cell Biology
IS - 1
ER -