Effects of vaccination with T cell receptor peptides: Epitope switching to a possible disease-protective determinant of myelin basic protein that is cross-reactive with a TCR BV peptide

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Abstract

Immunization of Lewis rats with guinea-pig myelin basic protein (Gp- MBP) induced T cell responses to primary and secondary encephalitogenic determinants, as well as to a third non-encephalitogenic epitope, residues 55-69. This sequence is of interest due to its protective activity against experimental autoimmune encephalomyelitis. Protection involved induction of MBP-55-69-specific T cells expressing cross-reactive TCR BV8S6 genes that activated regulatory T cells specific for TCR BV8S2 determinants expressed on encephalitogenic T cells. We here present and discuss new evidence suggesting a possible immunological cross-reactivity between the protective Gp-MBP-55- 69 peptide and the regulatory BV8S2-39-59 peptide. This cross-reactivity, which may also occur between the human MBP-55-74 peptide and the BV12S2-38- 58 sequence, has potentially important implications for human diseases such as multiple sclerosis.

Original languageEnglish (US)
Pages (from-to)83-90
Number of pages8
JournalImmunology and Cell Biology
Volume76
Issue number1
DOIs
StatePublished - May 11 1998

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Keywords

  • Cross-reactivity
  • Experimental autoimmune encephalomyelitis
  • Multiple sclerosis
  • Myelin basic protein
  • Regulatory T cells
  • T cell receptor peptides

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Cell Biology

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