Effects of subanesthetic intravenous ketamine infusion on corticosterone and brain-derived neurotrophic factor in the plasma of male Sprague-Dawley rats

CDR Kennett D. Radford, Thomas Y. Park, Lisa Osborne Smith, Kwang H. Choi

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Posttrauma anesthetic agents influence neuroendocrine responses that may affect fear memory. The effects of a subanesthetic intravenous (IV) ketamine infusion on mediators of stress and memory in rodents are unknown. Therefore, we used a clinically relevant method to administer a 2-hour subanesthetic IV ketamine infusion following a rodent fear-conditioning paradigm (paired tone plus foot shock) to evaluate the effects on corticosterone and brain-derived neurotrophic factor in the plasma of male Sprague-Dawley rats. We found that subanesthetic ketamine infusions (5 and 20 mg/kg/h) dose-dependently increased plasma corticosterone levels. Ketamine at 20 mg/kg/h significantly reduced plasma brain-derived neurotrophic factor measured 2 hours after the conclusion of the ketamine infusion. These results demonstrate that a subanesthetic IV ketamine infusion maintained a heightened neuroendocrine stress response after fear conditioning and reduced levels of a neurotrophin associated with memory, which may influence fear memory processing. The behavioral outcomes of these effects are unknown and warrant future investigation.

Original languageEnglish (US)
Pages (from-to)393-400
Number of pages8
JournalAANA journal
Volume86
Issue number5
StatePublished - Jan 1 2018

Keywords

  • BDNF
  • Corticosterone
  • Fear conditioning
  • Ketamine
  • Rats

ASJC Scopus subject areas

  • Medical–Surgical
  • Advanced and Specialized Nursing
  • Anesthesiology and Pain Medicine

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