Effects of subacute dietary salt intake and acute volume expansion on diastolic function in young normotensive individuals

Gary S. Mak, Heloisa Sawaya, Abigail May Khan, Pankaj Arora, Andrew Martinez, Allicia Ryan, Laura Ernande, Christopher Newton-Cheh, Thomas J. Wang, Marielle Scherrer-Crosbie

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

AimsChronic excess salt intake may have blood pressure-independent adverse effects on the heart such as myocardial hypertrophy and fibrosis. Effects of subacute sodium loading with excess dietary salt on diastolic function in normotensive individuals have been conflicting and the mechanisms are poorly understood.Methods and resultsThirteen healthy normotensive subjects (age 24 ± 4 years) entered a 2-week crossover study with 1 week of a low-salt diet <10 mEq/day and 1 week of a high-salt diet >200 mEq/day. At the end of each study week, left ventricular dimensions, systolic, and diastolic function were assessed with echocardiography before and after 2 L of normal saline infusion. One week of high-salt and low-salt diets did not lead to differences in echocardiographic parameters of systolic or diastolic function, even after rapid volume expansion with saline infusion. The peak early diastolic strain rate (SR) increased after volume loading both after completion of low-salt (1.62 ± 0.23/s vs. 1.82 ± 0.14/s, P < 0.05) and high-salt diets (1.67 ± 0.16/s vs. 1.86 ± 0.22/s, P < 0.05). There was a positive correlation between the peak early diastolic SR and the cardiac index (r = 0.52, P = 0.017).ConclusionIn healthy normotensive individuals, subacute excess dietary sodium intake does not affect diastolic function. The peak early diastolic SR, similar to other mitral Doppler and tissue Doppler parameters of diastolic function, appears to be strongly dependent on pre-load.

Original languageEnglish (US)
Pages (from-to)1092-1098
Number of pages7
JournalEuropean heart journal cardiovascular Imaging
Volume14
Issue number11
DOIs
StatePublished - Nov 2013

Keywords

  • Diastolic function
  • Diastolic strain rate
  • Sodium

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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    Mak, G. S., Sawaya, H., Khan, A. M., Arora, P., Martinez, A., Ryan, A., Ernande, L., Newton-Cheh, C., Wang, T. J., & Scherrer-Crosbie, M. (2013). Effects of subacute dietary salt intake and acute volume expansion on diastolic function in young normotensive individuals. European heart journal cardiovascular Imaging, 14(11), 1092-1098. https://doi.org/10.1093/ehjci/jet036