Effects of sub-lethal doses of cadmium chloride on native and phenobarbitone-induced drug metabolizing enzymes in male rabbits

F. Anjum; A. Raman; A. R. Shakoori; J. W. Gorrod

Effects of sub-lethal doses of cadmium chloride on native and phenobarbitone-induced drug metabolizing enzymes in male rabbits

F. Anjum, A. Raman, A. R. Shakoori, J. W. Gorrod

Research output: Contribution to journal › Article › peer-review

Abstract

Cadmium chloride (CdCl₂) pretreatment produced a marked decrease in the activity of the hepatic microsomal mono-oxygenase enzyme systems in male New Zealand white rabbits. Following in vivo sub-lethal doses (6 mg/kg i.p.) of CdCl₂ for 5 days, significant decreases in the levels of cytochrome P-450 and in the microsomal metabolism of a range of substrates were observed. Pretreatment of rabbits with phenobarbitone significantly increased the levels of cytochrome P-450 and also increased the metabolism of all the substrates used. The inhibition pattern produced by CdCl₂ remained the same in control and PB-pretreated rabbits. CdCl₂ treatment did not result in any change in the levels of cytochrome b₅ or cytochrome-c-reductase.

Original language	English (US)
Pages (from-to)	45-49
Number of pages	5
Journal	Pharmaceutical Science Communications
Volume	4
Issue number	1
State	Published - 1993
Externally published	Yes

Keywords

Acetanilide-4-hydroxylase
Aminopyrine-N-demethylase
Aniline-4-hydroxylase
Benzphetamine-N-demethylase,
Cadmium chloride
Cytochrome P-450
Cytochrome b
Cytochrome-c-reductase
N-demethylases
Phenobarbitone
Pretreatment
Rabbits

ASJC Scopus subject areas

Molecular Medicine
Pharmacology

Cite this

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title = "Effects of sub-lethal doses of cadmium chloride on native and phenobarbitone-induced drug metabolizing enzymes in male rabbits",

abstract = "Cadmium chloride (CdCl2) pretreatment produced a marked decrease in the activity of the hepatic microsomal mono-oxygenase enzyme systems in male New Zealand white rabbits. Following in vivo sub-lethal doses (6 mg/kg i.p.) of CdCl2 for 5 days, significant decreases in the levels of cytochrome P-450 and in the microsomal metabolism of a range of substrates were observed. Pretreatment of rabbits with phenobarbitone significantly increased the levels of cytochrome P-450 and also increased the metabolism of all the substrates used. The inhibition pattern produced by CdCl2 remained the same in control and PB-pretreated rabbits. CdCl2 treatment did not result in any change in the levels of cytochrome b5 or cytochrome-c-reductase.",

keywords = "Acetanilide-4-hydroxylase, Aminopyrine-N-demethylase, Aniline-4-hydroxylase, Benzphetamine-N-demethylase,, Cadmium chloride, Cytochrome P-450, Cytochrome b, Cytochrome-c-reductase, N-demethylases, Phenobarbitone, Pretreatment, Rabbits",

author = "F. Anjum and A. Raman and Shakoori, {A. R.} and Gorrod, {J. W.}",

year = "1993",

language = "English (US)",

volume = "4",

pages = "45--49",

journal = "Pharmaceutical Science Communications",

issn = "1351-6337",

number = "1",

}

TY - JOUR

T1 - Effects of sub-lethal doses of cadmium chloride on native and phenobarbitone-induced drug metabolizing enzymes in male rabbits

AU - Anjum, F.

AU - Raman, A.

AU - Shakoori, A. R.

AU - Gorrod, J. W.

PY - 1993

Y1 - 1993

N2 - Cadmium chloride (CdCl2) pretreatment produced a marked decrease in the activity of the hepatic microsomal mono-oxygenase enzyme systems in male New Zealand white rabbits. Following in vivo sub-lethal doses (6 mg/kg i.p.) of CdCl2 for 5 days, significant decreases in the levels of cytochrome P-450 and in the microsomal metabolism of a range of substrates were observed. Pretreatment of rabbits with phenobarbitone significantly increased the levels of cytochrome P-450 and also increased the metabolism of all the substrates used. The inhibition pattern produced by CdCl2 remained the same in control and PB-pretreated rabbits. CdCl2 treatment did not result in any change in the levels of cytochrome b5 or cytochrome-c-reductase.

AB - Cadmium chloride (CdCl2) pretreatment produced a marked decrease in the activity of the hepatic microsomal mono-oxygenase enzyme systems in male New Zealand white rabbits. Following in vivo sub-lethal doses (6 mg/kg i.p.) of CdCl2 for 5 days, significant decreases in the levels of cytochrome P-450 and in the microsomal metabolism of a range of substrates were observed. Pretreatment of rabbits with phenobarbitone significantly increased the levels of cytochrome P-450 and also increased the metabolism of all the substrates used. The inhibition pattern produced by CdCl2 remained the same in control and PB-pretreated rabbits. CdCl2 treatment did not result in any change in the levels of cytochrome b5 or cytochrome-c-reductase.

KW - Acetanilide-4-hydroxylase

KW - Aminopyrine-N-demethylase

KW - Aniline-4-hydroxylase

KW - Benzphetamine-N-demethylase,

KW - Cadmium chloride

KW - Cytochrome P-450

KW - Cytochrome b

KW - Cytochrome-c-reductase

KW - N-demethylases

KW - Phenobarbitone

KW - Pretreatment

KW - Rabbits

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M3 - Article

AN - SCOPUS:0027732333

SN - 1351-6337

VL - 4

SP - 45

EP - 49

JO - Pharmaceutical Science Communications

JF - Pharmaceutical Science Communications

IS - 1

ER -

Effects of sub-lethal doses of cadmium chloride on native and phenobarbitone-induced drug metabolizing enzymes in male rabbits

Abstract

Keywords

ASJC Scopus subject areas

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