Effects of sub-lethal doses of cadmium chloride on native and phenobarbitone-induced drug metabolizing enzymes in male rabbits

F. Anjum, A. Raman, A. R. Shakoori, J. W. Gorrod

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Cadmium chloride (CdCl2) pretreatment produced a marked decrease in the activity of the hepatic microsomal mono-oxygenase enzyme systems in male New Zealand white rabbits. Following in vivo sub-lethal doses (6 mg/kg i.p.) of CdCl2 for 5 days, significant decreases in the levels of cytochrome P-450 and in the microsomal metabolism of a range of substrates were observed. Pretreatment of rabbits with phenobarbitone significantly increased the levels of cytochrome P-450 and also increased the metabolism of all the substrates used. The inhibition pattern produced by CdCl2 remained the same in control and PB-pretreated rabbits. CdCl2 treatment did not result in any change in the levels of cytochrome b5 or cytochrome-c-reductase.

Original languageEnglish (US)
Pages (from-to)45-49
Number of pages5
JournalPharmaceutical Science Communications
Volume4
Issue number1
StatePublished - Dec 1 1993

Keywords

  • Acetanilide-4-hydroxylase
  • Aminopyrine-N-demethylase
  • Aniline-4-hydroxylase
  • Benzphetamine-N-demethylase,
  • Cadmium chloride
  • Cytochrome P-450
  • Cytochrome b
  • Cytochrome-c-reductase
  • N-demethylases
  • Phenobarbitone
  • Pretreatment
  • Rabbits

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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