Effects of spleen status on early outcomes after hematopoietic cell transplantation

G. Akpek, M. C. Pasquini, B. Logan, M. A. Agovi, H. M. Lazarus, D. I. Marks, M. Bornhaeüser, O. Ringdén, Richard Maziarz, V. Gupta, U. Popat, D. Maharaj, B. J. Bolwell, J. D. Rizzo, K. K. Ballen, K. R. Cooke, P. L. McCarthy, V. T. Ho

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

To assess the impact of spleen status on engraftment, and early morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT), we analyzed 9,683 myeloablative allograft recipients from 1990 to 2006; 472 had prior splenectomy (SP), 300 splenic irradiation (SI), 1,471 with splenomegaly (SM), and 7,440 with normal spleen (NS). Median times to neutrophil engraftment (NE) and platelet engraftment (PE) were 15 vs 18 days and 22 vs 24 days for the SP and NS groups, respectively (P5.7 × 10 6/kg improved PE at day+28. After adjusting variables by Cox regression, the incidence of GVHD and OS were not different among groups. SM is associated with delayed engraftment, whereas SP prior to HCT facilitates early engraftment without having an impact on survival.

Original languageEnglish (US)
Pages (from-to)825-831
Number of pages7
JournalBone Marrow Transplantation
Volume48
Issue number6
DOIs
StatePublished - Jun 2013

Fingerprint

Cell Transplantation
Splenectomy
Spleen
Splenomegaly
Blood Platelets
Allografts
Neutrophils
Morbidity
Mortality
Incidence

Keywords

  • engraftment
  • myeloproliferative disease
  • SCT
  • spleen
  • splenectomy

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Akpek, G., Pasquini, M. C., Logan, B., Agovi, M. A., Lazarus, H. M., Marks, D. I., ... Ho, V. T. (2013). Effects of spleen status on early outcomes after hematopoietic cell transplantation. Bone Marrow Transplantation, 48(6), 825-831. https://doi.org/10.1038/bmt.2012.249

Effects of spleen status on early outcomes after hematopoietic cell transplantation. / Akpek, G.; Pasquini, M. C.; Logan, B.; Agovi, M. A.; Lazarus, H. M.; Marks, D. I.; Bornhaeüser, M.; Ringdén, O.; Maziarz, Richard; Gupta, V.; Popat, U.; Maharaj, D.; Bolwell, B. J.; Rizzo, J. D.; Ballen, K. K.; Cooke, K. R.; McCarthy, P. L.; Ho, V. T.

In: Bone Marrow Transplantation, Vol. 48, No. 6, 06.2013, p. 825-831.

Research output: Contribution to journalArticle

Akpek, G, Pasquini, MC, Logan, B, Agovi, MA, Lazarus, HM, Marks, DI, Bornhaeüser, M, Ringdén, O, Maziarz, R, Gupta, V, Popat, U, Maharaj, D, Bolwell, BJ, Rizzo, JD, Ballen, KK, Cooke, KR, McCarthy, PL & Ho, VT 2013, 'Effects of spleen status on early outcomes after hematopoietic cell transplantation', Bone Marrow Transplantation, vol. 48, no. 6, pp. 825-831. https://doi.org/10.1038/bmt.2012.249
Akpek, G. ; Pasquini, M. C. ; Logan, B. ; Agovi, M. A. ; Lazarus, H. M. ; Marks, D. I. ; Bornhaeüser, M. ; Ringdén, O. ; Maziarz, Richard ; Gupta, V. ; Popat, U. ; Maharaj, D. ; Bolwell, B. J. ; Rizzo, J. D. ; Ballen, K. K. ; Cooke, K. R. ; McCarthy, P. L. ; Ho, V. T. / Effects of spleen status on early outcomes after hematopoietic cell transplantation. In: Bone Marrow Transplantation. 2013 ; Vol. 48, No. 6. pp. 825-831.
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