Vliv specifické inhibice cyklooxygenázy 2 na ledvinové funkce u starších pacientů s poruchou ledvinové funkce

Translated title of the contribution: Effects of specific cycloxygenase- 2 inhibition on the renal functions of elderly patients with renal function impairment

M. Horáčková, O. Schück, R. Komers, V. Teplan, J. Charvát, M. Kvapil

Research output: Contribution to journalArticle

Abstract

Background. Elderly patients suffering from nociceptive pain of locomotive organs and concomitantly from renal impairment represent a target population for painkilling drugs. That is why they are predisposed to nephrotoxic effects non-steroidal anti-inflammatory drugs. The aim of our study was to evaluate cycloxygenase-2 (COX-2) inhibition effect on renal function in elderly with moderate impairment of renal function. Methods and Results. Based on 24-h urine collection we assessed creatinine clearance (CCr), fractional excretion of sodium (FENa), potassium (FEK), chloride (FECl), osmotic active solutes (FEOSM) and 24h urinary excretion of prostaglandin PGE2 and PGF. Under conditions of sub-maximal water load fractional excretion of electrolytes, inulin clearance (Cin), serum cystatin C (Scyst) were assessed. In addition basal and stimulated plasma renin activity (PRA) and plasma aldosteron (Paldo) were examined. Using comparison of parameters before and at the end of 7-days rofecoxib treatment we found out Cin 0,82±0,34 vs 0,74±0,18 ml/s/1,73 m2, FENa 1,0±0,3 vs 1,2±0,4 (p=0,02), FEOSM 2,9±0,7 vs 3,7±1,2% (p=0,03), UPGE2α V 663±528 vs 414±195 (p=0,059), UPGF2 V (559±625) vs 205±174 ηg/24h (p=0,02), stimulated PRA 0,94±0,73 vs 0,4±0,27 ±pg/1/h (p=0,019), Paldo 104,56±50,15 vs 56,94±27,08 ηg/l/h (p=0,008). Conclusions. Short-term COX-2 inhibition in patients with moderate renal impairment was associated with significant decrease of tubular transport of sodium, without changing GFR and water excretion.

Original languageUndefined
Pages (from-to)777-781
Number of pages5
JournalCasopis Lekaru Ceskych
Volume145
Issue number10
StatePublished - 2006
Externally publishedYes

Fingerprint

Kidney
Renin
Sodium
Nociceptive Pain
Cystatin C
Urine Specimen Collection
Dinoprost
Inulin
Potassium Chloride
Water
Health Services Needs and Demand
Dinoprostone
Pharmaceutical Preparations
Electrolytes
Prostaglandins
Creatinine
Anti-Inflammatory Agents
Serum
Therapeutics
rofecoxib

Keywords

  • Coclooxygenase-2 inhibition
  • Renal function
  • Renal insufficiency

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Horáčková, M., Schück, O., Komers, R., Teplan, V., Charvát, J., & Kvapil, M. (2006). Vliv specifické inhibice cyklooxygenázy 2 na ledvinové funkce u starších pacientů s poruchou ledvinové funkce. Casopis Lekaru Ceskych, 145(10), 777-781.

Vliv specifické inhibice cyklooxygenázy 2 na ledvinové funkce u starších pacientů s poruchou ledvinové funkce. / Horáčková, M.; Schück, O.; Komers, R.; Teplan, V.; Charvát, J.; Kvapil, M.

In: Casopis Lekaru Ceskych, Vol. 145, No. 10, 2006, p. 777-781.

Research output: Contribution to journalArticle

Horáčková, M, Schück, O, Komers, R, Teplan, V, Charvát, J & Kvapil, M 2006, 'Vliv specifické inhibice cyklooxygenázy 2 na ledvinové funkce u starších pacientů s poruchou ledvinové funkce', Casopis Lekaru Ceskych, vol. 145, no. 10, pp. 777-781.
Horáčková M, Schück O, Komers R, Teplan V, Charvát J, Kvapil M. Vliv specifické inhibice cyklooxygenázy 2 na ledvinové funkce u starších pacientů s poruchou ledvinové funkce. Casopis Lekaru Ceskych. 2006;145(10):777-781.
Horáčková, M. ; Schück, O. ; Komers, R. ; Teplan, V. ; Charvát, J. ; Kvapil, M. / Vliv specifické inhibice cyklooxygenázy 2 na ledvinové funkce u starších pacientů s poruchou ledvinové funkce. In: Casopis Lekaru Ceskych. 2006 ; Vol. 145, No. 10. pp. 777-781.
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abstract = "Background. Elderly patients suffering from nociceptive pain of locomotive organs and concomitantly from renal impairment represent a target population for painkilling drugs. That is why they are predisposed to nephrotoxic effects non-steroidal anti-inflammatory drugs. The aim of our study was to evaluate cycloxygenase-2 (COX-2) inhibition effect on renal function in elderly with moderate impairment of renal function. Methods and Results. Based on 24-h urine collection we assessed creatinine clearance (CCr), fractional excretion of sodium (FENa), potassium (FEK), chloride (FECl), osmotic active solutes (FEOSM) and 24h urinary excretion of prostaglandin PGE2 and PGF2α. Under conditions of sub-maximal water load fractional excretion of electrolytes, inulin clearance (Cin), serum cystatin C (Scyst) were assessed. In addition basal and stimulated plasma renin activity (PRA) and plasma aldosteron (Paldo) were examined. Using comparison of parameters before and at the end of 7-days rofecoxib treatment we found out Cin 0,82±0,34 vs 0,74±0,18 ml/s/1,73 m2, FENa 1,0±0,3 vs 1,2±0,4 (p=0,02), FEOSM 2,9±0,7 vs 3,7±1,2{\%} (p=0,03), UPGE2α V 663±528 vs 414±195 (p=0,059), UPGF2 V (559±625) vs 205±174 ηg/24h (p=0,02), stimulated PRA 0,94±0,73 vs 0,4±0,27 ±pg/1/h (p=0,019), Paldo 104,56±50,15 vs 56,94±27,08 ηg/l/h (p=0,008). Conclusions. Short-term COX-2 inhibition in patients with moderate renal impairment was associated with significant decrease of tubular transport of sodium, without changing GFR and water excretion.",
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T1 - Vliv specifické inhibice cyklooxygenázy 2 na ledvinové funkce u starších pacientů s poruchou ledvinové funkce

AU - Horáčková, M.

AU - Schück, O.

AU - Komers, R.

AU - Teplan, V.

AU - Charvát, J.

AU - Kvapil, M.

PY - 2006

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N2 - Background. Elderly patients suffering from nociceptive pain of locomotive organs and concomitantly from renal impairment represent a target population for painkilling drugs. That is why they are predisposed to nephrotoxic effects non-steroidal anti-inflammatory drugs. The aim of our study was to evaluate cycloxygenase-2 (COX-2) inhibition effect on renal function in elderly with moderate impairment of renal function. Methods and Results. Based on 24-h urine collection we assessed creatinine clearance (CCr), fractional excretion of sodium (FENa), potassium (FEK), chloride (FECl), osmotic active solutes (FEOSM) and 24h urinary excretion of prostaglandin PGE2 and PGF2α. Under conditions of sub-maximal water load fractional excretion of electrolytes, inulin clearance (Cin), serum cystatin C (Scyst) were assessed. In addition basal and stimulated plasma renin activity (PRA) and plasma aldosteron (Paldo) were examined. Using comparison of parameters before and at the end of 7-days rofecoxib treatment we found out Cin 0,82±0,34 vs 0,74±0,18 ml/s/1,73 m2, FENa 1,0±0,3 vs 1,2±0,4 (p=0,02), FEOSM 2,9±0,7 vs 3,7±1,2% (p=0,03), UPGE2α V 663±528 vs 414±195 (p=0,059), UPGF2 V (559±625) vs 205±174 ηg/24h (p=0,02), stimulated PRA 0,94±0,73 vs 0,4±0,27 ±pg/1/h (p=0,019), Paldo 104,56±50,15 vs 56,94±27,08 ηg/l/h (p=0,008). Conclusions. Short-term COX-2 inhibition in patients with moderate renal impairment was associated with significant decrease of tubular transport of sodium, without changing GFR and water excretion.

AB - Background. Elderly patients suffering from nociceptive pain of locomotive organs and concomitantly from renal impairment represent a target population for painkilling drugs. That is why they are predisposed to nephrotoxic effects non-steroidal anti-inflammatory drugs. The aim of our study was to evaluate cycloxygenase-2 (COX-2) inhibition effect on renal function in elderly with moderate impairment of renal function. Methods and Results. Based on 24-h urine collection we assessed creatinine clearance (CCr), fractional excretion of sodium (FENa), potassium (FEK), chloride (FECl), osmotic active solutes (FEOSM) and 24h urinary excretion of prostaglandin PGE2 and PGF2α. Under conditions of sub-maximal water load fractional excretion of electrolytes, inulin clearance (Cin), serum cystatin C (Scyst) were assessed. In addition basal and stimulated plasma renin activity (PRA) and plasma aldosteron (Paldo) were examined. Using comparison of parameters before and at the end of 7-days rofecoxib treatment we found out Cin 0,82±0,34 vs 0,74±0,18 ml/s/1,73 m2, FENa 1,0±0,3 vs 1,2±0,4 (p=0,02), FEOSM 2,9±0,7 vs 3,7±1,2% (p=0,03), UPGE2α V 663±528 vs 414±195 (p=0,059), UPGF2 V (559±625) vs 205±174 ηg/24h (p=0,02), stimulated PRA 0,94±0,73 vs 0,4±0,27 ±pg/1/h (p=0,019), Paldo 104,56±50,15 vs 56,94±27,08 ηg/l/h (p=0,008). Conclusions. Short-term COX-2 inhibition in patients with moderate renal impairment was associated with significant decrease of tubular transport of sodium, without changing GFR and water excretion.

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