Effects of short-term treatment with testosterone on the secretion of FSH and LH in castrated golden hamsters exposed to short days

Henryk Urbanski, S. M. Simpson

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Castrated hamsters which were transferred from long (14L:10D) to short (9L:15D) days and received testosterone-filled capsules for 1 week after transfer failed to show a significant suppression in the plasma levels of FSH and LH after capsule removal. In contrast, gonadotrophin concentrations were suppressed in hamsters in which the long-day castration response had been blocked with exogenous testosterone. After castration on long days and exposure to 10 weeks of short days pituitary gland weight and gonadotrophin content, as well as plasma FSH titres, were higher in control animals than in those that had received testosterone implants for 7 weeks of short days. The results suggest that failure of castrated hamsters to respond to the suppressive effects of short days reflects castration-induced changes in hypothalamo-pituitary physiology rather than a neuroendocrine mechanism by which photoperiod modulates gonadotrophin secretion.

Original languageEnglish (US)
Pages (from-to)489-496
Number of pages8
JournalJournal of Reproduction and Fertility
Volume69
Issue number2
StatePublished - 1983
Externally publishedYes

Fingerprint

Castration
Mesocricetus
Cricetinae
Testosterone
Gonadotropins
Capsules
Pituitary Gonadotropins
Photoperiod
Pituitary Gland
Weights and Measures

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Physiology
  • Embryology
  • Obstetrics and Gynecology

Cite this

@article{5e52ea9b90c24aa7a0d0e9e75ddab4bd,
title = "Effects of short-term treatment with testosterone on the secretion of FSH and LH in castrated golden hamsters exposed to short days",
abstract = "Castrated hamsters which were transferred from long (14L:10D) to short (9L:15D) days and received testosterone-filled capsules for 1 week after transfer failed to show a significant suppression in the plasma levels of FSH and LH after capsule removal. In contrast, gonadotrophin concentrations were suppressed in hamsters in which the long-day castration response had been blocked with exogenous testosterone. After castration on long days and exposure to 10 weeks of short days pituitary gland weight and gonadotrophin content, as well as plasma FSH titres, were higher in control animals than in those that had received testosterone implants for 7 weeks of short days. The results suggest that failure of castrated hamsters to respond to the suppressive effects of short days reflects castration-induced changes in hypothalamo-pituitary physiology rather than a neuroendocrine mechanism by which photoperiod modulates gonadotrophin secretion.",
author = "Henryk Urbanski and Simpson, {S. M.}",
year = "1983",
language = "English (US)",
volume = "69",
pages = "489--496",
journal = "Journal of Reproduction and Fertility",
issn = "0022-4251",
publisher = "Society for Reproduction and Fertility",
number = "2",

}

TY - JOUR

T1 - Effects of short-term treatment with testosterone on the secretion of FSH and LH in castrated golden hamsters exposed to short days

AU - Urbanski, Henryk

AU - Simpson, S. M.

PY - 1983

Y1 - 1983

N2 - Castrated hamsters which were transferred from long (14L:10D) to short (9L:15D) days and received testosterone-filled capsules for 1 week after transfer failed to show a significant suppression in the plasma levels of FSH and LH after capsule removal. In contrast, gonadotrophin concentrations were suppressed in hamsters in which the long-day castration response had been blocked with exogenous testosterone. After castration on long days and exposure to 10 weeks of short days pituitary gland weight and gonadotrophin content, as well as plasma FSH titres, were higher in control animals than in those that had received testosterone implants for 7 weeks of short days. The results suggest that failure of castrated hamsters to respond to the suppressive effects of short days reflects castration-induced changes in hypothalamo-pituitary physiology rather than a neuroendocrine mechanism by which photoperiod modulates gonadotrophin secretion.

AB - Castrated hamsters which were transferred from long (14L:10D) to short (9L:15D) days and received testosterone-filled capsules for 1 week after transfer failed to show a significant suppression in the plasma levels of FSH and LH after capsule removal. In contrast, gonadotrophin concentrations were suppressed in hamsters in which the long-day castration response had been blocked with exogenous testosterone. After castration on long days and exposure to 10 weeks of short days pituitary gland weight and gonadotrophin content, as well as plasma FSH titres, were higher in control animals than in those that had received testosterone implants for 7 weeks of short days. The results suggest that failure of castrated hamsters to respond to the suppressive effects of short days reflects castration-induced changes in hypothalamo-pituitary physiology rather than a neuroendocrine mechanism by which photoperiod modulates gonadotrophin secretion.

UR - http://www.scopus.com/inward/record.url?scp=0020613583&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020613583&partnerID=8YFLogxK

M3 - Article

C2 - 6415274

AN - SCOPUS:0020613583

VL - 69

SP - 489

EP - 496

JO - Journal of Reproduction and Fertility

JF - Journal of Reproduction and Fertility

SN - 0022-4251

IS - 2

ER -