TY - JOUR
T1 - Effects of short-term dietary glucose and fructose on rat serum triglyceride concentration
AU - Merkens, L. S.
AU - Tepperman, H. M.
AU - Tepperman, J.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1980
Y1 - 1980
N2 - The effect of dietary fructose on serum triglyceride (TG) concentration was studied in rats. First, after only 3 days the mean serum TG level in rats fed fructose was higher (124±13 mg/100 ml; N = 8) than in rats fed glucose (84±6; N = 7) or starch (85±7); N = 8). Second, because rats are nocturnal feeders we measured the serum TG and insulin concentrations throughout a 24-hour period. The rats fed fructose had large diurnal fluctuations in TG; the highest concentrations occurred at night. The TG levels in rats fed fructose were greater than those in rats fed glucose at all times during the 24-hour period except at 1700 hours. Serum insulin concentrations were the same in rats fed fructose or glucose. Thus, the effect of fructose on serum TG was not mediated by a change in serum insulin. Third, we measured the effect of fructose on the ratio of TG (mg) to protein (mg) in the chylomicron and very low density lipoprotein serum fraction. This ratio was slightly lower in the rats fed fructose (17±0.5; N = 9) than in rats fed glucose (22±2.2; N = 7). The excess TG in the serum of rats fed fructose was not disproportionately composed of large lipoproteins. Fourth, we determined if the effect of dietary fructose could be maintained when the release of TG from the liver was prevented by dietary orotic acid. The serum TG concentrations were the same in rats fed orotic acid with either glucose (44±5; N = 8) or fructose (46±6; N = 8). Thus, the TG released from the liver was necessary for dietary fructose to increase serum TG.
AB - The effect of dietary fructose on serum triglyceride (TG) concentration was studied in rats. First, after only 3 days the mean serum TG level in rats fed fructose was higher (124±13 mg/100 ml; N = 8) than in rats fed glucose (84±6; N = 7) or starch (85±7); N = 8). Second, because rats are nocturnal feeders we measured the serum TG and insulin concentrations throughout a 24-hour period. The rats fed fructose had large diurnal fluctuations in TG; the highest concentrations occurred at night. The TG levels in rats fed fructose were greater than those in rats fed glucose at all times during the 24-hour period except at 1700 hours. Serum insulin concentrations were the same in rats fed fructose or glucose. Thus, the effect of fructose on serum TG was not mediated by a change in serum insulin. Third, we measured the effect of fructose on the ratio of TG (mg) to protein (mg) in the chylomicron and very low density lipoprotein serum fraction. This ratio was slightly lower in the rats fed fructose (17±0.5; N = 9) than in rats fed glucose (22±2.2; N = 7). The excess TG in the serum of rats fed fructose was not disproportionately composed of large lipoproteins. Fourth, we determined if the effect of dietary fructose could be maintained when the release of TG from the liver was prevented by dietary orotic acid. The serum TG concentrations were the same in rats fed orotic acid with either glucose (44±5; N = 8) or fructose (46±6; N = 8). Thus, the TG released from the liver was necessary for dietary fructose to increase serum TG.
UR - http://www.scopus.com/inward/record.url?scp=0019313157&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019313157&partnerID=8YFLogxK
U2 - 10.1093/jn/110.5.982
DO - 10.1093/jn/110.5.982
M3 - Article
C2 - 6989966
AN - SCOPUS:0019313157
SN - 0022-3166
VL - 110
SP - 982
EP - 988
JO - Journal of Nutrition
JF - Journal of Nutrition
IS - 5
ER -