TY - JOUR
T1 - Effects of sex on object recognition and spatial navigation in humans
AU - Rizk-Jackson, Angela M.
AU - Acevedo, Summer F.
AU - Inman, Dean
AU - Howieson, Diane
AU - Benice, Theodore S.
AU - Raber, Jacob
N1 - Funding Information:
We would like to thank Aaron Cram at the Oregon Research Institute for his contributions and support of the virtual reality software used in this study, Clive Woffendin and his staff at the Oregon Health and Science University General Clinical Research Center for their assistance with hormonal assays, and Gary Sexton, Kenneth James, and Shannon McWheeny for their advice with regard to the statistical analyses. This work was supported by EMF AG-NS-0201 (JR), the Medical Research Foundation of Oregon (JR), a Pilot Project of the Layton Center for Aging and Alzheimer's Disease (JR), PHS Grant 5 M01 RR000334, and Alzheimer's Disease Center NIA Grant P30 AG08017.
PY - 2006/10/16
Y1 - 2006/10/16
N2 - Human tests designed to mirror rodent tests of object recognition and spatial navigation were administered to adult cognitively healthy humans. Facial recognition was also assessed. There was no sex difference in facial recognition, consistent with earlier studies. In the object recognition test, the test-retest NINL total scores during the same visit were highly correlated, comparable to the test-retest correlations obtained in the established facial recognition test. There were no effects of sex on object recognition. However, in the spatial navigation test, there were effects of sex on spatial learning and memory during the session with the hidden, but not visible, target. These tests might be useful to compare assessments of object recognition and spatial learning and memory in humans and animal models.
AB - Human tests designed to mirror rodent tests of object recognition and spatial navigation were administered to adult cognitively healthy humans. Facial recognition was also assessed. There was no sex difference in facial recognition, consistent with earlier studies. In the object recognition test, the test-retest NINL total scores during the same visit were highly correlated, comparable to the test-retest correlations obtained in the established facial recognition test. There were no effects of sex on object recognition. However, in the spatial navigation test, there were effects of sex on spatial learning and memory during the session with the hidden, but not visible, target. These tests might be useful to compare assessments of object recognition and spatial learning and memory in humans and animal models.
KW - Facial recognition
KW - Novel location recognition
KW - Sex differences
KW - Virtual maze
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U2 - 10.1016/j.bbr.2006.06.029
DO - 10.1016/j.bbr.2006.06.029
M3 - Article
C2 - 16887201
AN - SCOPUS:33748170259
SN - 0166-4328
VL - 173
SP - 181
EP - 190
JO - Behavioural Brain Research
JF - Behavioural Brain Research
IS - 2
ER -