Effects of sex on mechanical embolectomy outcome

Helmi Lutsep, Michael D. Hill

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Given that women have demonstrated a greater margin of benefit than men from treatment with thrombolytics in certain acute stroke trials, the current study explored whether this sex effect extends to mechanical embolectomy and can be explained by revascularization rate. The study included the 305 patients enrolled in the Mechanical Embolus Removal in Cerebral Ischemia (MERCI) and Multi MERCI trials. Demographic, risk factor, and procedural characteristics were evaluated in women and men. Odds ratios for outcomes by sex were compared in patients with revascularization and those without revascularization, defined as a Thrombolysis in Myocardial Infarction score of 2-3 at the end of the procedure. Outcomes included a modified Rankin Scale (mRS) score of 0-2 and mortality at 90 days, as well as the presence of symptomatic intracranial hemorrhage (sICH). Patient and procedural characteristics did not differ between women and men except for mean age (women, 70.1 years; men, 64.8 years; P =.003), hypertension (women, 78.0%; men, 65.5%; P =.021), and number of vertebrobasilar occlusions (women, 8/159 [5.0%]; men, 20/146 [13.7%]; P =.01). Revascularization was significantly associated with favorable outcomes in both women and men (P

Original languageEnglish (US)
Pages (from-to)240-242
Number of pages3
JournalJournal of Stroke and Cerebrovascular Diseases
Volume21
Issue number3
DOIs
StatePublished - Apr 2012

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Embolectomy
Embolism
Brain Ischemia
Intracranial Hemorrhages
Stroke
Odds Ratio
Myocardial Infarction
Demography
Hypertension
Mortality

Keywords

  • Acute stroke
  • cerebral infarct
  • stroke
  • women

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery
  • Rehabilitation
  • Cardiology and Cardiovascular Medicine

Cite this

Effects of sex on mechanical embolectomy outcome. / Lutsep, Helmi; Hill, Michael D.

In: Journal of Stroke and Cerebrovascular Diseases, Vol. 21, No. 3, 04.2012, p. 240-242.

Research output: Contribution to journalArticle

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