Effects of s-emopamil, nimodipine, and mild hypothermia on hippocampal glutamate concentrations after repeated cerebral ischemia in rabbits

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Abstract

Background and Purpose: We sought to determine the effects of two different calcium channel antagonists, S-emopamil and nimodipine, on hippocampal glutamate and glycine release and to compare their effects to those of mild hypothermia. Methods: New Zealand White rabbits were subjected to two 7.5-minute episodes of global cerebral ischemia at a 1-hour interval produced by neck tourniquet inflation (20 psi) combined with hypotension during halothane anesthesia. Hippocampal extracellular concentrations of glutamate and glycine were monitored using in vivo microdialysis. Animals were randomized to receive either S-emopamil (1 mg * kg−1bolus, 0.1 mg. kg−1 min−1• infusion), nimodipine (10 µg • kg−1 bolus, 1 µg • kg−1 • min−1 infusion), hypothermia (32°C), or saline (control) before ischemia. Drug infusion and hypothermia were continued throughout the study periods. Results: In all four groups, both ischemic episodes resulted in significant elevations of hippocampal extracellular concentrations of glutamate and glycine (baseline vs peak, P

Original languageEnglish (US)
Pages (from-to)1228-1234
Number of pages7
JournalStroke
Volume24
Issue number8
StatePublished - 1993
Externally publishedYes

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