Effects of s-emopamil, nimodipine, and mild hypothermia on hippocampal glutamate concentrations after repeated cerebral ischemia in rabbits

Mishiya Matsumoto, Mark S. Scheller, Mark Zornow, Martin A P Strnat

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background and Purpose: We sought to determine the effects of two different calcium channel antagonists, S-emopamil and nimodipine, on hippocampal glutamate and glycine release and to compare their effects to those of mild hypothermia. Methods: New Zealand White rabbits were subjected to two 7.5-minute episodes of global cerebral ischemia at a 1-hour interval produced by neck tourniquet inflation (20 psi) combined with hypotension during halothane anesthesia. Hippocampal extracellular concentrations of glutamate and glycine were monitored using in vivo microdialysis. Animals were randomized to receive either S-emopamil (1 mg * kg−1bolus, 0.1 mg. kg−1 min−1• infusion), nimodipine (10 µg • kg−1 bolus, 1 µg • kg−1 • min−1 infusion), hypothermia (32°C), or saline (control) before ischemia. Drug infusion and hypothermia were continued throughout the study periods. Results: In all four groups, both ischemic episodes resulted in significant elevations of hippocampal extracellular concentrations of glutamate and glycine (baseline vs peak, P

Original languageEnglish (US)
Pages (from-to)1228-1234
Number of pages7
JournalStroke
Volume24
Issue number8
StatePublished - 1993
Externally publishedYes

Fingerprint

Nimodipine
Hypothermia
Brain Ischemia
Glycine
Glutamic Acid
Rabbits
Tourniquets
Microdialysis
Economic Inflation
Calcium Channel Blockers
Halothane
Hypotension
Neck
Ischemia
Anesthesia
Pharmaceutical Preparations
emopamil

Keywords

  • Calcium channel blockers
  • Cerebral ischemia
  • Glutamates
  • Rabbits

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing
  • Neuroscience(all)

Cite this

Effects of s-emopamil, nimodipine, and mild hypothermia on hippocampal glutamate concentrations after repeated cerebral ischemia in rabbits. / Matsumoto, Mishiya; Scheller, Mark S.; Zornow, Mark; Strnat, Martin A P.

In: Stroke, Vol. 24, No. 8, 1993, p. 1228-1234.

Research output: Contribution to journalArticle

Matsumoto, Mishiya ; Scheller, Mark S. ; Zornow, Mark ; Strnat, Martin A P. / Effects of s-emopamil, nimodipine, and mild hypothermia on hippocampal glutamate concentrations after repeated cerebral ischemia in rabbits. In: Stroke. 1993 ; Vol. 24, No. 8. pp. 1228-1234.
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