Effects of radiofrequency catheter ablation on regional myocardial blood flow: Possible mechanism for late electrophysiological outcome

Sunil Nath, James G. Whayne, Sanjiv Kaul, N. Craig Goodman, Ananda R. Jayaweera, David E. Haines

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Background: We postulated that the late electrophysiological effects of radiofrequency (RF) ablation may be related to microvascular injury extending beyond the region of acute coagulation necrosis. Methods and Results: Eighteen RF lesions created in the left anterior descending coronary artery (LAD) perfusion bed of seven open chest anesthetized dogs were studied. The ablation electrode and surrounding myocardium were imaged using high- resolution two-dimensional echocardiography at x4 magnification. After 60 seconds of RF delivery, sonicated albumin microbubbles (mean size, 4.3 μm) were injected into the LAD to measure regional myocardial perfusion, and time-intensity plots were generated from simultaneously acquired two- dimensional echocardiography images. The regions with persistent contrast effect on two-dimensional echocardiography were larger than the pathological lesions (mean cross-sectional area, 48.3±6.3 versus 19.3±4.7 mm2, respectively; P

Original languageEnglish (US)
Pages (from-to)2667-2672
Number of pages6
JournalCirculation
Volume89
Issue number6
StatePublished - Jun 1994
Externally publishedYes

Fingerprint

Catheter Ablation
Regional Blood Flow
Echocardiography
Perfusion
Microbubbles
Albumins
Coronary Vessels
Myocardium
Electrodes
Necrosis
Thorax
Dogs
Wounds and Injuries

Keywords

  • ablation
  • catheters
  • microvasculature
  • radiofrequency

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Nath, S., Whayne, J. G., Kaul, S., Goodman, N. C., Jayaweera, A. R., & Haines, D. E. (1994). Effects of radiofrequency catheter ablation on regional myocardial blood flow: Possible mechanism for late electrophysiological outcome. Circulation, 89(6), 2667-2672.

Effects of radiofrequency catheter ablation on regional myocardial blood flow : Possible mechanism for late electrophysiological outcome. / Nath, Sunil; Whayne, James G.; Kaul, Sanjiv; Goodman, N. Craig; Jayaweera, Ananda R.; Haines, David E.

In: Circulation, Vol. 89, No. 6, 06.1994, p. 2667-2672.

Research output: Contribution to journalArticle

Nath, Sunil ; Whayne, James G. ; Kaul, Sanjiv ; Goodman, N. Craig ; Jayaweera, Ananda R. ; Haines, David E. / Effects of radiofrequency catheter ablation on regional myocardial blood flow : Possible mechanism for late electrophysiological outcome. In: Circulation. 1994 ; Vol. 89, No. 6. pp. 2667-2672.
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