Effects of Positive End‐Expiratory Pressure on Renal Function

P. ‐O Järnberg, E. Dominguez de Villota, J. Eklund, P. ‐O Granberg

Research output: Contribution to journalArticle

35 Scopus citations


The effects were studied of positive end‐expiratory pressure (PEEP) on renal function in eight patients with acute respiratory failure, requiring mechanical ventilation. On application of PEEP+ 10 cmH2O, central venous pressure increased, systolic blood pressure decreased, urine flow and PAH‐clearance were reduced, while inulin clearance remained stable. There was a marked increase in fractional sodium reabsorption and a concurrent decrease in fractional osmolal excretion. Fractional free‐water clearance and the ratio Uosm/Posm did not change.

Original languageEnglish (US)
Pages (from-to)508-514
Number of pages7
JournalActa Anaesthesiologica Scandinavica
Issue number5
StatePublished - Oct 1978

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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