Effects of oral magnesium supplementation on acute experimental cyclosporin nephrotoxicity

E. A. Burdmann, T. F. Andoh, J. Lindsley, Donald Houghton, W. M. Bennett

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Hypomagnesaemia with magnesuria are common findings in cyclosporin-(CsA)-treated patients and have been proposed as both a cause and a consequence of nephrotoxicity. To investigate the role of Mg depletion in the pathogenesis of acute CsA nephrotoxicity, rats kept on a low-salt diet were maintained on plain water (Mg(-)group) or water supplemented with 2% MgCl2 (Mg(+)group) and randomly assigned to treatment with CsA 15 mg/kg (CsA) or vehicle (VH) s.c. for 7 days. Water and food ingestion in VH animals was adjusted to the intake of CsA animals. CsAMg(-) group showed a significant plasma magnesium (PMg) reduction as compared to baseline (1.13 versus 1.53 mg/dl, P <0.001) or VH values (versus 1.60 mg/dl, P <0.001) and a significantly greater post-treatment fractional excretion of magnesium (FeMg) as compared to VH (9.4 versus 5.4%, P <0.01). Magnesium supplementation increased PMg (2.11 versus 1.57 mg/dl P <0.001) and FeMg (13.6 versus 6.2%, P <0.001) but did not prevent a reduction in GFR with CsA treatment. Alanine aminopeptidase (AAP) excretion at 7 days was significantly greater than baseline (130 versus 44 IU/gCr, P <0.05) or VH (36 IU/gCr, P <0.05) values only in the CsAMg(-) rats. No differences were observed in intraerythrocyte Mg, blood pressure, and urinary excretion of N-acetyl-β-D-glucosaminidase among groups. Renal histology was similar in CsA rats independent of magnesium supplementation: mild vacuolization and tubular collapse in proximal tubules. In conclusion, Mg depletion could not be implicated in the pathogenesis of acute CsA-induced glomerular dysfunction, but Mg replacement may protect from some of the tubular toxicity of CsA.

Original languageEnglish (US)
Pages (from-to)16-21
Number of pages6
JournalNephrology Dialysis Transplantation
Volume9
Issue number1
StatePublished - 1994

Fingerprint

Magnesium
Cyclosporine
Water
CD13 Antigens
Sodium-Restricted Diet
Hexosaminidases
Magnesium Chloride
Histology
Therapeutics
Eating
Blood Pressure
Kidney
Food

Keywords

  • Cyclosporin
  • Enzymuria
  • Magnesium
  • Nephrotoxicity
  • Rats
  • Renal function

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Effects of oral magnesium supplementation on acute experimental cyclosporin nephrotoxicity. / Burdmann, E. A.; Andoh, T. F.; Lindsley, J.; Houghton, Donald; Bennett, W. M.

In: Nephrology Dialysis Transplantation, Vol. 9, No. 1, 1994, p. 16-21.

Research output: Contribution to journalArticle

Burdmann, E. A. ; Andoh, T. F. ; Lindsley, J. ; Houghton, Donald ; Bennett, W. M. / Effects of oral magnesium supplementation on acute experimental cyclosporin nephrotoxicity. In: Nephrology Dialysis Transplantation. 1994 ; Vol. 9, No. 1. pp. 16-21.
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