Effects of oral and intramuscular carbaryl administrations on repeated chain acquisition in monkeys

Wyndham Anger, J. V. Setzer

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A type of learning task was utilized to determine the effective dose of carbaryl on Macaca fascicularis for both oral and im routes of administration. Monkeys were required to press four buttons in a set order; the order was changed daily. A baseline reversal design was utilized to test all animals several times at each concentration. The im carbaryl injections resulted in consistent, statistically reliable decrements in total session time and increases in errors at 5 and 10 mg/kg for the 4 animals in this section of the experiment, but produced no change in performance at 1 mg/kg. Errors increased in 3 of 4 monkeys after 3 mg/kg injections. Oral doses as high as 50 mg/kg were not consistently effective in changing performance on the task in any of 5 animals included in this section of the experiment. Some support was given to the suggestion that monkeys are more tolerant of carbaryl than are rats. These are the first reported effects (other than the LD50) of carbaryl in monkeys.

Original languageEnglish (US)
Pages (from-to)793-808
Number of pages16
JournalJournal of Toxicology and Environmental Health
Volume5
Issue number5
StatePublished - 1979
Externally publishedYes

Fingerprint

Carbaryl
Haplorhini
Animals
Injections
Macaca fascicularis
Rats
Lethal Dose 50
Task Performance and Analysis
Experiments
Learning

ASJC Scopus subject areas

  • Pollution
  • Toxicology

Cite this

Effects of oral and intramuscular carbaryl administrations on repeated chain acquisition in monkeys. / Anger, Wyndham; Setzer, J. V.

In: Journal of Toxicology and Environmental Health, Vol. 5, No. 5, 1979, p. 793-808.

Research output: Contribution to journalArticle

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