Effects of Omega-3 Fatty Acids on Heart Rate in Cardiac Transplant Recipients††Disclaimer: Saint Luke's Hospital holds a minority interest in OmegaMetrix, LLC, Kansas City, Missouri, a company offering blood omega-3 fatty acid testing.

William Harris, Michael Gonzales, Nathan Laney, Antonio Sastre, A. Michael Borkon

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Omega-3 fatty acid (n-3 FA) consumption has been linked to reductions in the risk of death from coronary heart disease and, recently, to lower heart rates (HRs). The investigators previously observed a reduction of 5 beats/min in HR in patients with coronary heart disease given n-3 FAs (eicosapentaenoic acid and docosahexaenoic acid) for 4 months. Reductions in HR may be explained by enhanced vagal tone, influences on cardiac voltage-gated ion channels, or both. The hypothesis that n-3 FAs would affect HR independent of vagal input was investigated by studying the effects of n-3 FA supplementation on HR in patients with denervated hearts after orthotopic heart transplantation. Electrocardiographic data obtained in 2 prospective trials in which 18 heart transplant recipients received n-3 FA supplementation (1 to 3.4 g/day) for 4 to 6 months were collected. Patients were studied 4.4 ± 2.6 years after transplantation. HR, QRS complex, and QTc duration were determined before and after treatment. Pretreatment HR was reduced from 88 ± 14 to 83 ± 13 beats/min after n-3 FA treatment (p = 0.016). QRS duration increased from 107 ± 24 to 117 ± 25 ms (p = 0.001). QTc duration remained unchanged from baseline (427 ± 34 ms) to study end (424 ± 39 ms). In conclusion, n-3 FA supplementation reduced HR and prolonged QRS duration in heart transplant recipients who were presumably devoid of vagal innervation. These findings suggest that n-3 FAs may modify electrophysiologic properties of the myocardium itself.

Original languageEnglish (US)
Pages (from-to)1393-1395
Number of pages3
JournalAmerican Journal of Cardiology
Volume98
Issue number10
DOIs
StatePublished - Nov 15 2006
Externally publishedYes

Fingerprint

Omega-3 Fatty Acids
Heart Rate
Transplants
Coronary Disease
Eicosapentaenoic Acid
Docosahexaenoic Acids
Risk Reduction Behavior
Heart Transplantation
Ion Channels
Myocardium
Transplantation
Research Personnel
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Effects of Omega-3 Fatty Acids on Heart Rate in Cardiac Transplant Recipients††Disclaimer : Saint Luke's Hospital holds a minority interest in OmegaMetrix, LLC, Kansas City, Missouri, a company offering blood omega-3 fatty acid testing. / Harris, William; Gonzales, Michael; Laney, Nathan; Sastre, Antonio; Borkon, A. Michael.

In: American Journal of Cardiology, Vol. 98, No. 10, 15.11.2006, p. 1393-1395.

Research output: Contribution to journalArticle

@article{482cb0ffd9a04744a7beaaf26c35288e,
title = "Effects of Omega-3 Fatty Acids on Heart Rate in Cardiac Transplant Recipients††Disclaimer: Saint Luke's Hospital holds a minority interest in OmegaMetrix, LLC, Kansas City, Missouri, a company offering blood omega-3 fatty acid testing.",
abstract = "Omega-3 fatty acid (n-3 FA) consumption has been linked to reductions in the risk of death from coronary heart disease and, recently, to lower heart rates (HRs). The investigators previously observed a reduction of 5 beats/min in HR in patients with coronary heart disease given n-3 FAs (eicosapentaenoic acid and docosahexaenoic acid) for 4 months. Reductions in HR may be explained by enhanced vagal tone, influences on cardiac voltage-gated ion channels, or both. The hypothesis that n-3 FAs would affect HR independent of vagal input was investigated by studying the effects of n-3 FA supplementation on HR in patients with denervated hearts after orthotopic heart transplantation. Electrocardiographic data obtained in 2 prospective trials in which 18 heart transplant recipients received n-3 FA supplementation (1 to 3.4 g/day) for 4 to 6 months were collected. Patients were studied 4.4 ± 2.6 years after transplantation. HR, QRS complex, and QTc duration were determined before and after treatment. Pretreatment HR was reduced from 88 ± 14 to 83 ± 13 beats/min after n-3 FA treatment (p = 0.016). QRS duration increased from 107 ± 24 to 117 ± 25 ms (p = 0.001). QTc duration remained unchanged from baseline (427 ± 34 ms) to study end (424 ± 39 ms). In conclusion, n-3 FA supplementation reduced HR and prolonged QRS duration in heart transplant recipients who were presumably devoid of vagal innervation. These findings suggest that n-3 FAs may modify electrophysiologic properties of the myocardium itself.",
author = "William Harris and Michael Gonzales and Nathan Laney and Antonio Sastre and Borkon, {A. Michael}",
year = "2006",
month = "11",
day = "15",
doi = "10.1016/j.amjcard.2006.06.033",
language = "English (US)",
volume = "98",
pages = "1393--1395",
journal = "American Journal of Cardiology",
issn = "0002-9149",
publisher = "Elsevier Inc.",
number = "10",

}

TY - JOUR

T1 - Effects of Omega-3 Fatty Acids on Heart Rate in Cardiac Transplant Recipients††Disclaimer

T2 - Saint Luke's Hospital holds a minority interest in OmegaMetrix, LLC, Kansas City, Missouri, a company offering blood omega-3 fatty acid testing.

AU - Harris, William

AU - Gonzales, Michael

AU - Laney, Nathan

AU - Sastre, Antonio

AU - Borkon, A. Michael

PY - 2006/11/15

Y1 - 2006/11/15

N2 - Omega-3 fatty acid (n-3 FA) consumption has been linked to reductions in the risk of death from coronary heart disease and, recently, to lower heart rates (HRs). The investigators previously observed a reduction of 5 beats/min in HR in patients with coronary heart disease given n-3 FAs (eicosapentaenoic acid and docosahexaenoic acid) for 4 months. Reductions in HR may be explained by enhanced vagal tone, influences on cardiac voltage-gated ion channels, or both. The hypothesis that n-3 FAs would affect HR independent of vagal input was investigated by studying the effects of n-3 FA supplementation on HR in patients with denervated hearts after orthotopic heart transplantation. Electrocardiographic data obtained in 2 prospective trials in which 18 heart transplant recipients received n-3 FA supplementation (1 to 3.4 g/day) for 4 to 6 months were collected. Patients were studied 4.4 ± 2.6 years after transplantation. HR, QRS complex, and QTc duration were determined before and after treatment. Pretreatment HR was reduced from 88 ± 14 to 83 ± 13 beats/min after n-3 FA treatment (p = 0.016). QRS duration increased from 107 ± 24 to 117 ± 25 ms (p = 0.001). QTc duration remained unchanged from baseline (427 ± 34 ms) to study end (424 ± 39 ms). In conclusion, n-3 FA supplementation reduced HR and prolonged QRS duration in heart transplant recipients who were presumably devoid of vagal innervation. These findings suggest that n-3 FAs may modify electrophysiologic properties of the myocardium itself.

AB - Omega-3 fatty acid (n-3 FA) consumption has been linked to reductions in the risk of death from coronary heart disease and, recently, to lower heart rates (HRs). The investigators previously observed a reduction of 5 beats/min in HR in patients with coronary heart disease given n-3 FAs (eicosapentaenoic acid and docosahexaenoic acid) for 4 months. Reductions in HR may be explained by enhanced vagal tone, influences on cardiac voltage-gated ion channels, or both. The hypothesis that n-3 FAs would affect HR independent of vagal input was investigated by studying the effects of n-3 FA supplementation on HR in patients with denervated hearts after orthotopic heart transplantation. Electrocardiographic data obtained in 2 prospective trials in which 18 heart transplant recipients received n-3 FA supplementation (1 to 3.4 g/day) for 4 to 6 months were collected. Patients were studied 4.4 ± 2.6 years after transplantation. HR, QRS complex, and QTc duration were determined before and after treatment. Pretreatment HR was reduced from 88 ± 14 to 83 ± 13 beats/min after n-3 FA treatment (p = 0.016). QRS duration increased from 107 ± 24 to 117 ± 25 ms (p = 0.001). QTc duration remained unchanged from baseline (427 ± 34 ms) to study end (424 ± 39 ms). In conclusion, n-3 FA supplementation reduced HR and prolonged QRS duration in heart transplant recipients who were presumably devoid of vagal innervation. These findings suggest that n-3 FAs may modify electrophysiologic properties of the myocardium itself.

UR - http://www.scopus.com/inward/record.url?scp=33750521789&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750521789&partnerID=8YFLogxK

U2 - 10.1016/j.amjcard.2006.06.033

DO - 10.1016/j.amjcard.2006.06.033

M3 - Article

C2 - 17134636

AN - SCOPUS:33750521789

VL - 98

SP - 1393

EP - 1395

JO - American Journal of Cardiology

JF - American Journal of Cardiology

SN - 0002-9149

IS - 10

ER -