Effects of omega-3 acid ethyl esters and aspirin, alone and in combination, on platelet function in healthy subjects

Mark K. Larson, Joseph H. Ashmore, Kristina A. Harris, Jessica L. Vogelaar, James V. Pottala, Michael Sprehe, William Harris

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Omega-3 fatty acids (n-3 FA) from oily fish are clinically useful for lowering triglycerides and reducing risk of heart attacks.Accordingly, patients at risk are often advised to take both aspirin and n-3 FA. However, both of these agents can increase bleeding times, and the extent to which the combination inhibits platelet function is unknown.The purpose of this pilot study was to determine the effects of a prescription omega-3 FA product (P-OM3) and aspirin, alone and in combination, on platelet aggregation assessed by whole blood impedance aggregometry (WBA).Ten healthy volunteers provided blood samples on four separate occasions: Day 1, baseline; Day 2, one day after taking aspirin (2 x 325 mg tablets); Day 29, after 28 days of P-OM3 (4 capsules/day); and Day 30, after one day of combined P-OM3 and aspirin. WBA was tested with two concentrations of collagen, with ADP and with a thrombin receptor activating peptide (TRAP). Compared to baseline, aspirin alone inhibited aggregation only with low-dose collagen stimulation; P-OM3 alone did not inhibit aggregation with any agonist; and combined therapy inhibited aggregation with all agonists but TRAP. Significant interactions between interventions were not observed in response to any agonist. In conclusion, P-OM3 alone did not inhibit platelet aggregation, but did (with two agonists) when combined with aspirin. Since previous studies have not reported a clinically significant risk for bleeding in subjects on combined therapy, P-OM3 may safely enhance the anti-platelet effect of aspirin.

Original languageEnglish (US)
Pages (from-to)634-641
Number of pages8
JournalThrombosis and Haemostasis
Volume100
Issue number4
DOIs
StatePublished - Oct 2008
Externally publishedYes

Fingerprint

Aspirin
Healthy Volunteers
Esters
Blood Platelets
thrombin receptor peptide SFLLRNP
Acids
Electric Impedance
Platelet Aggregation
Collagen
Bleeding Time
Omega-3 Fatty Acids
Adenosine Diphosphate
Tablets
Capsules
Prescriptions
Fishes
Triglycerides
Myocardial Infarction
Hemorrhage
Therapeutics

Keywords

  • Aspirin
  • Docosahexaenoic acid
  • Eicosapentaenoic acid
  • Omega-3 fatty acids
  • Platelet aggregation

ASJC Scopus subject areas

  • Hematology

Cite this

Larson, M. K., Ashmore, J. H., Harris, K. A., Vogelaar, J. L., Pottala, J. V., Sprehe, M., & Harris, W. (2008). Effects of omega-3 acid ethyl esters and aspirin, alone and in combination, on platelet function in healthy subjects. Thrombosis and Haemostasis, 100(4), 634-641. https://doi.org/10.1160/TH08-02-0084

Effects of omega-3 acid ethyl esters and aspirin, alone and in combination, on platelet function in healthy subjects. / Larson, Mark K.; Ashmore, Joseph H.; Harris, Kristina A.; Vogelaar, Jessica L.; Pottala, James V.; Sprehe, Michael; Harris, William.

In: Thrombosis and Haemostasis, Vol. 100, No. 4, 10.2008, p. 634-641.

Research output: Contribution to journalArticle

Larson, MK, Ashmore, JH, Harris, KA, Vogelaar, JL, Pottala, JV, Sprehe, M & Harris, W 2008, 'Effects of omega-3 acid ethyl esters and aspirin, alone and in combination, on platelet function in healthy subjects', Thrombosis and Haemostasis, vol. 100, no. 4, pp. 634-641. https://doi.org/10.1160/TH08-02-0084
Larson, Mark K. ; Ashmore, Joseph H. ; Harris, Kristina A. ; Vogelaar, Jessica L. ; Pottala, James V. ; Sprehe, Michael ; Harris, William. / Effects of omega-3 acid ethyl esters and aspirin, alone and in combination, on platelet function in healthy subjects. In: Thrombosis and Haemostasis. 2008 ; Vol. 100, No. 4. pp. 634-641.
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