Effects of nicotine on brain 1-phosphatidylinositol-4-phosphate and 1-phosphatidylinositol-3,4-bisphosphate synthesis and metabolism-possible relationship to nicotine-induced behaviors

Robert J. Hitzemann, Reiko Natsuki, Horace H. Loh

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The effects of nicotine and other cholinergic drugs on the initial incorporation of 32Pi, and [3H]glycerol into 1-phosphatidylinositol-4-phosphate(DPI)and 1-phosphatidylinsitol-3,4-bisphosphate (TPI) in the rat brain microsomal fraction were studied. Nicotine and eserine significantly decreased and mecamylamine increased [32P]- and [3H]TPI levels. Atropine had no effect on labeled TPI levels. Dose-effect studies for nicotine revealed that as little as 0.1 mg/kg of nicotine, i.p., significantly decreased the accumulation of labeled TPI. It was concluded that pharmacologically relevant and nonconvulsive doses of nicotine can markedly affect brain polyphosphoinositide synthesis and/or metabolism; the nature of the effects is consistent with theories suggesting that the conversion of TPI to DPI will release membrane lipid bound Ca2+ and, thus, increase membrane excitability.

Original languageEnglish (US)
Pages (from-to)2519-2523
Number of pages5
JournalBiochemical Pharmacology
Volume27
Issue number21
DOIs
StatePublished - 1978

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

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