Effects of niacin and omega-3 fatty acids on the apolipoproteins in overweight patients with elevated triglycerides and reduced HDL cholesterol

Olga V. Savinova, Kristi Fillaus, William Harris, Gregory C. Shearer

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective: Prescription omega-3 acid ethyl esters (P-OM3) and extended release niacin (ERN) both have beneficial effects on plasma lipids and lipoproteins. The purpose of this study was to describe the effects of mono- and combination (Combo) therapy of these agents in patients with the metabolic syndrome. Methods: Very low density (VLDL), intermediate/low density (IDL/LDL, hereafter LDL), and high density lipoproteins (HDL) were isolated from 56 overweight patients with elevated triglyceride/HDL-C ratios at baseline and after 16 weeks of treatment with placebo, ERN (2g/day), P-OM3 (4g/day), or Combo and then analyzed by quantitative electrophoresis for apolipoproteins (apo) A1, A2, B, C2, C3 and E. Total plasma concentrations and the ratios of each apo with apoB (in VLDL and LDL) and with apoA1 (in HDL) were calculated. An apoC3 glycosylation index (a ratio between di- and mono-sialylated isoforms) was also determined in plasma and in each lipoprotein fraction. Results: ERN reduced plasma apoB (-11%, p

Original languageEnglish (US)
Pages (from-to)520-525
Number of pages6
JournalAtherosclerosis
Volume240
Issue number2
DOIs
StatePublished - Jun 1 2015
Externally publishedYes

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Apolipoproteins
Niacin
Omega-3 Fatty Acids
HDL Cholesterol
Triglycerides
HDL Lipoproteins
Apolipoproteins B
Lipoproteins
Apolipoprotein A-II
Apolipoprotein A-I
Proxy
Glycosylation
Prescriptions
Electrophoresis
Protein Isoforms
Esters
Placebos
Lipids
Acids
Therapeutics

Keywords

  • Apolipoproteins
  • Extended release niacin
  • Prescription omega-3 acid ethyl ester

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Effects of niacin and omega-3 fatty acids on the apolipoproteins in overweight patients with elevated triglycerides and reduced HDL cholesterol. / Savinova, Olga V.; Fillaus, Kristi; Harris, William; Shearer, Gregory C.

In: Atherosclerosis, Vol. 240, No. 2, 01.06.2015, p. 520-525.

Research output: Contribution to journalArticle

Savinova, Olga V. ; Fillaus, Kristi ; Harris, William ; Shearer, Gregory C. / Effects of niacin and omega-3 fatty acids on the apolipoproteins in overweight patients with elevated triglycerides and reduced HDL cholesterol. In: Atherosclerosis. 2015 ; Vol. 240, No. 2. pp. 520-525.
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