Effects of methotrexate on transfected DNA stability in mammalian cells

Maria G. Pallavicini, Patricia S. Deteresa, Caridad Rosette, Joe W. Gray, Florian M. Wurm

Research output: Contribution to journalArticle

76 Scopus citations


The chromosomal locations, amounts, and level of expression of transfected, amplified c-myc and dihydrofolate reductase sequences were measured in cells cultured in the presence and absence of methotrexate. These studies show that the location and amount of transfected sequences, as well as the level of expression, were more variable when the cells were cultured in methotrexate.

Original languageEnglish (US)
Pages (from-to)401-404
Number of pages4
JournalMolecular and cellular biology
Issue number1
StatePublished - Jan 1990

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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