TY - JOUR
T1 - Effects of marine-derived omega-3 fatty acids on systemic hemodynamics at rest and during stress
T2 - A dose-response study
AU - Skulas-Ray, Ann C.
AU - Kris-Etherton, Penny M.
AU - Harris, William S.
AU - West, Sheila G.
N1 - Funding Information:
Acknowledgments This study was funded by a scholarship grant from the National Fisheries Institute. Study materials (capsules) and additional financial support was provided by Reliant Pharmaceuticals (now Glax-oSmithKline, GSK). Financial supporters had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript. We are grateful to Danette L. Teeter for her analysis of the impedance cardiography results. Katherine A. Sauder provided valuable assistance with revision of the manuscript. We are also grateful to the nursing and clinician staff of the General Clinical Research Center of The Pennsylvania State University, which was supported by NIH Grant M01 RR 10732.
PY - 2012/12
Y1 - 2012/12
N2 - Background: Omega-3 fatty acids reduced heart rate (HR) and blood pressure (BP) in some studies, but dose-response studies are rare, and little is known about underlying mechanisms. Purpose: We examined effects of 0.85 g/day eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) (low dose) and 3.4 g/day EPA + DHA (high dose) on HR and systemic hemodynamics during rest, speech, and foot cold pressor tasks. Methods: This was a dose-response, placebo-controlled, double-blind, randomized, crossover trial (8-week treatment, 6-week washout) in 26 adults. Results: Throughout the testing sessions, HR was reduced in a dose-dependent manner. The high dose reduced BP and stroke volume and increased pre-ejection period. Reductions in BP were associated with increases in erythrocyte omega-3 fatty acids. Conclusions: High-dose long-chain omega-3 fatty acids can reduce BP and HR, at rest and during stress. These findings suggest that at-risk populations may achieve benefits with increased omega-3 intake. The trial was registered on ClinicalTrials.gov (NCT00504309).
AB - Background: Omega-3 fatty acids reduced heart rate (HR) and blood pressure (BP) in some studies, but dose-response studies are rare, and little is known about underlying mechanisms. Purpose: We examined effects of 0.85 g/day eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) (low dose) and 3.4 g/day EPA + DHA (high dose) on HR and systemic hemodynamics during rest, speech, and foot cold pressor tasks. Methods: This was a dose-response, placebo-controlled, double-blind, randomized, crossover trial (8-week treatment, 6-week washout) in 26 adults. Results: Throughout the testing sessions, HR was reduced in a dose-dependent manner. The high dose reduced BP and stroke volume and increased pre-ejection period. Reductions in BP were associated with increases in erythrocyte omega-3 fatty acids. Conclusions: High-dose long-chain omega-3 fatty acids can reduce BP and HR, at rest and during stress. These findings suggest that at-risk populations may achieve benefits with increased omega-3 intake. The trial was registered on ClinicalTrials.gov (NCT00504309).
KW - Acute stress
KW - Fish
KW - Hemodynamics
KW - Omega-3
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U2 - 10.1007/s12160-012-9393-2
DO - 10.1007/s12160-012-9393-2
M3 - Article
C2 - 22865498
AN - SCOPUS:84872273588
SN - 0883-6612
VL - 44
SP - 301
EP - 308
JO - Annals of Behavioral Medicine
JF - Annals of Behavioral Medicine
IS - 3
ER -