Effects of marine-derived omega-3 fatty acids on systemic hemodynamics at rest and during stress

A dose-response study

Ann C. Skulas-Ray, Penny M. Kris-Etherton, William Harris, Sheila G. West

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Omega-3 fatty acids reduced heart rate (HR) and blood pressure (BP) in some studies, but dose-response studies are rare, and little is known about underlying mechanisms. Purpose: We examined effects of 0.85 g/day eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) (low dose) and 3.4 g/day EPA + DHA (high dose) on HR and systemic hemodynamics during rest, speech, and foot cold pressor tasks. Methods: This was a dose-response, placebo-controlled, double-blind, randomized, crossover trial (8-week treatment, 6-week washout) in 26 adults. Results: Throughout the testing sessions, HR was reduced in a dose-dependent manner. The high dose reduced BP and stroke volume and increased pre-ejection period. Reductions in BP were associated with increases in erythrocyte omega-3 fatty acids. Conclusions: High-dose long-chain omega-3 fatty acids can reduce BP and HR, at rest and during stress. These findings suggest that at-risk populations may achieve benefits with increased omega-3 intake. The trial was registered on ClinicalTrials.gov (NCT00504309).

Original languageEnglish (US)
Pages (from-to)301-308
Number of pages8
JournalAnnals of Behavioral Medicine
Volume44
Issue number3
DOIs
StatePublished - Dec 2012
Externally publishedYes

Fingerprint

Omega-3 Fatty Acids
Heart Rate
Hemodynamics
Blood Pressure
Eicosapentaenoic Acid
Docosahexaenoic Acids
Blood Volume
Stroke Volume
Cross-Over Studies
Foot
Erythrocytes
Placebos
Therapeutics

Keywords

  • Acute stress
  • Fish
  • Hemodynamics
  • Omega-3

ASJC Scopus subject areas

  • Psychology(all)
  • Psychiatry and Mental health
  • Medicine(all)

Cite this

Effects of marine-derived omega-3 fatty acids on systemic hemodynamics at rest and during stress : A dose-response study. / Skulas-Ray, Ann C.; Kris-Etherton, Penny M.; Harris, William; West, Sheila G.

In: Annals of Behavioral Medicine, Vol. 44, No. 3, 12.2012, p. 301-308.

Research output: Contribution to journalArticle

Skulas-Ray, Ann C. ; Kris-Etherton, Penny M. ; Harris, William ; West, Sheila G. / Effects of marine-derived omega-3 fatty acids on systemic hemodynamics at rest and during stress : A dose-response study. In: Annals of Behavioral Medicine. 2012 ; Vol. 44, No. 3. pp. 301-308.
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