Effects of leuprolide-induced hypogonadism and testosterone replacement on sleep, melatonin, and prolactin secretion in men

Ellen Leibenluft, Peter J. Schmidt, Erick Turner, Merry A. Danaceau, Sharon B. Ashman, Thomas A. Wehr, David R. Rubinow

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The possible role of gonadal steroids in regulating sleep and circadian rhythms in humans has received relatively little attention despite the importance of the topic to several clinical syndromes. Pharmacologically induced hypogonadism, with and without gonadal steroid replacement, provides an opportunity to examine these questions within a controlled experimental design. We used leuprolide acetate, with and without testosterone replacement, to study the role of testosterone in the regulation of sleep and of melatonin. PRL, and TSH secretion in men. Results from 10 men revealed significant decreases in 24-h PRL levels and in the percentage and time of stage 4 sleep in the hypogonadal state compared with testosterone replacement. There were no differences in melatonin or TSH secretion or in the timing or duration of sleep between the two hormonal conditions. These results indicate that testostorone has relatively specific and discrete effects on sleep and hormonal rhythms in men.

Original languageEnglish (US)
Pages (from-to)3203-3207
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume82
Issue number10
DOIs
StatePublished - 1997
Externally publishedYes

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Leuprolide
Hypogonadism
Melatonin
Prolactin
Testosterone
Sleep
Steroids
Sleep Stages
Circadian Rhythm
Research Design
Design of experiments

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Effects of leuprolide-induced hypogonadism and testosterone replacement on sleep, melatonin, and prolactin secretion in men. / Leibenluft, Ellen; Schmidt, Peter J.; Turner, Erick; Danaceau, Merry A.; Ashman, Sharon B.; Wehr, Thomas A.; Rubinow, David R.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 82, No. 10, 1997, p. 3203-3207.

Research output: Contribution to journalArticle

Leibenluft, Ellen ; Schmidt, Peter J. ; Turner, Erick ; Danaceau, Merry A. ; Ashman, Sharon B. ; Wehr, Thomas A. ; Rubinow, David R. / Effects of leuprolide-induced hypogonadism and testosterone replacement on sleep, melatonin, and prolactin secretion in men. In: Journal of Clinical Endocrinology and Metabolism. 1997 ; Vol. 82, No. 10. pp. 3203-3207.
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