Effects of lesions of prefrontal cortex, amygdala, or fornix on behavioral sensitization to amphetamine: Comparison with N-methyl-d-aspartate antagonists

Marina Wolf, S. L. Dahlin, X. T. Hu, C. J. Xue, K. White

Research output: Contribution to journalArticle

245 Citations (Scopus)

Abstract

Behavioral sensitization to amphetamine involves the mesoaccumbens dopamine system and is accompanied by cellular changes in this system. Excitatory amino acid antagonists, when co-administered with amphetamine, prevent both behavioral sensitization and associated changes in the mesoaccumbens dopamine system. This suggests that excitatory amino acid-dependent events are critical to the initiation of sensitization. This study sought to identify excitatory amino acid projections required for sensitization, focusing on projections to the nucleus accumbens or ventral tegmental area. The major excitatory projections to the nucleus accumbens originate in the prefrontal cortex, amygdala and hippocampus. The prefrontal cortex and amygdala also send excitatory projections to the ventral tegmental area. Ibotenic acid lesions of the prefrontal cortex or amygdala and electrolytic lesions of the fornix were performed in rats. After one week of recovery, rats were treated with water or 2.5 mg/kg amphetamine for six days and challenged with amphetamine on day 8. Activity was tested in photobeam cages on days 1 and 8. On day 1, control and sham-lesioned rats exhibited stereotyped behaviors followed by a period of post-stereotypy locomotion. On day 8, sensitization was evident as an enhancement of both stereotypy and post-stereotypy locomotion. Co-administration of N-methyl-d-aspartate antagonists [MK-801 (dizocilpine maleate) or CGS 19755] with amphetamine prevented the development of sensitization of both stereotypy and post-stereotypy locomotion. Neither antagonist, however, prevented the expression of sensitization. None of the lesions completely mimicked these effects of N-methyl-d-aspartate antagonists. Lesions of hippocampal projections traveling in the fornix produced a general disinhibition of locomotor activity, but did not prevent sensitization of either stereotypy or post-stereotypy locomotion. Lesions of the prefrontal cortex failed to prevent sensitization of stereotypy, but eliminated sensitization of post-stereotypy locomotion. Lesions of the amygdala produced a significant increase in the intensity of stereotyped behaviors elicited by acute amphetamine, but further sensitization of stereotypy was obtained following repeated amphetamine administratio. However, like prefrontal cortical lesions, amygdala lesions prevented sensitization of post-stereotypy locomotion. When interpreted in the light of previous studies demonstrating the importance of the ventral tegmental area in the initiation of sensitization, the present results suggest a likely role for neuronal circuits area in the initiation of sensitization, the present results suggest a likely role for neuronal circuits involving the prefrontal cortex, amygdala and ventral tegmental area in the development of sensitization of post-stereotypy locomotion following repeated amphetamine administration. Such circuits may initiate sensitization through a mechanism involving excitatory amino acid regulation of the activity of mesoaccumbens dopamine neurons. Parallel circuits, involving other brain regions, may similarly contribute to sensitization of stereotyped behaviors.

Original languageEnglish (US)
Pages (from-to)417-439
Number of pages23
JournalNeuroscience
Volume69
Issue number2
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

Fingerprint

Amphetamine
Locomotion
Amygdala
Prefrontal Cortex
Aspartic Acid
Ventral Tegmental Area
Stereotyped Behavior
Excitatory Amino Acids
Dizocilpine Maleate
selfotel
Nucleus Accumbens
Dopamine
Ibotenic Acid
Excitatory Amino Acid Antagonists
Dopaminergic Neurons
Hippocampus
Water
Brain

Keywords

  • AMPA
  • DA
  • dizocilpine maleate
  • dopamine
  • EAA
  • excitatory amino acid
  • excitatory amino acids
  • mesolimbic dopamine neurons
  • MK-801
  • N-methyl-d-aspartate
  • NMDA
  • nucleus accumbens
  • ventral tegmental area
  • α-amino-3-hydroxy-5-methyl-4-isoaxolepropionate

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Effects of lesions of prefrontal cortex, amygdala, or fornix on behavioral sensitization to amphetamine : Comparison with N-methyl-d-aspartate antagonists. / Wolf, Marina; Dahlin, S. L.; Hu, X. T.; Xue, C. J.; White, K.

In: Neuroscience, Vol. 69, No. 2, 01.01.1995, p. 417-439.

Research output: Contribution to journalArticle

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AB - Behavioral sensitization to amphetamine involves the mesoaccumbens dopamine system and is accompanied by cellular changes in this system. Excitatory amino acid antagonists, when co-administered with amphetamine, prevent both behavioral sensitization and associated changes in the mesoaccumbens dopamine system. This suggests that excitatory amino acid-dependent events are critical to the initiation of sensitization. This study sought to identify excitatory amino acid projections required for sensitization, focusing on projections to the nucleus accumbens or ventral tegmental area. The major excitatory projections to the nucleus accumbens originate in the prefrontal cortex, amygdala and hippocampus. The prefrontal cortex and amygdala also send excitatory projections to the ventral tegmental area. Ibotenic acid lesions of the prefrontal cortex or amygdala and electrolytic lesions of the fornix were performed in rats. After one week of recovery, rats were treated with water or 2.5 mg/kg amphetamine for six days and challenged with amphetamine on day 8. Activity was tested in photobeam cages on days 1 and 8. On day 1, control and sham-lesioned rats exhibited stereotyped behaviors followed by a period of post-stereotypy locomotion. On day 8, sensitization was evident as an enhancement of both stereotypy and post-stereotypy locomotion. Co-administration of N-methyl-d-aspartate antagonists [MK-801 (dizocilpine maleate) or CGS 19755] with amphetamine prevented the development of sensitization of both stereotypy and post-stereotypy locomotion. Neither antagonist, however, prevented the expression of sensitization. None of the lesions completely mimicked these effects of N-methyl-d-aspartate antagonists. Lesions of hippocampal projections traveling in the fornix produced a general disinhibition of locomotor activity, but did not prevent sensitization of either stereotypy or post-stereotypy locomotion. Lesions of the prefrontal cortex failed to prevent sensitization of stereotypy, but eliminated sensitization of post-stereotypy locomotion. Lesions of the amygdala produced a significant increase in the intensity of stereotyped behaviors elicited by acute amphetamine, but further sensitization of stereotypy was obtained following repeated amphetamine administratio. However, like prefrontal cortical lesions, amygdala lesions prevented sensitization of post-stereotypy locomotion. When interpreted in the light of previous studies demonstrating the importance of the ventral tegmental area in the initiation of sensitization, the present results suggest a likely role for neuronal circuits area in the initiation of sensitization, the present results suggest a likely role for neuronal circuits involving the prefrontal cortex, amygdala and ventral tegmental area in the development of sensitization of post-stereotypy locomotion following repeated amphetamine administration. Such circuits may initiate sensitization through a mechanism involving excitatory amino acid regulation of the activity of mesoaccumbens dopamine neurons. Parallel circuits, involving other brain regions, may similarly contribute to sensitization of stereotyped behaviors.

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KW - N-methyl-d-aspartate

KW - NMDA

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KW - ventral tegmental area

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