Effects of intravascular infusions of plasma on placental and systemic blood flow in fetal sheep

George Giraud, J. Job Faber, Sonnet Jonker, Lowell Davis, Debra Anderson

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Six singleton fetal sheep of 118-122 days gestational age were instrumented with flow sensors on the brachiocephalic artery, the postductal aorta, and the common umbilical artery and with arterial and venous intravascular catheters. At 125-131 days of gestation, we started week-long continuous recordings of flows and pressures. After control measures had been obtained, the fetuses were given continuous intravenous infusions of adult sheep plasma at an initial rate of 229 ml/day. After 1 wk of infusion, fetal plasma protein concentrations had increased from 34 to 78 g/l, arterial and venous pressures had increased from 42 to 64 and from 2.7 to 3.7 mmHg, and systemic resistance (exclusive of the coronary bed) had increased from 0.047 to 0.075 mmHg·min -1·ml-1, whereas placental resistance had increased from 0.065 to 0.111 mmHg·min-1·ml-1. Fetal plasma renin activities fell as early as 1 day after the start of infusion and remained below control (all changes P <0.05). All flows decreased slightly although these decreases were not statistically significant. Thus the increase in arterial pressure was entirely due to an increase in systemic and placental resistances.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume291
Issue number6
DOIs
StatePublished - 2006

Fingerprint

Sheep
Arterial Pressure
Fetal Proteins
Umbilical Arteries
Venous Pressure
Renin
Intravenous Infusions
Gestational Age
Aorta
Blood Proteins
Fetus
Catheters
Arteries
Pressure
Pregnancy

Keywords

  • Blood pressure
  • Fetal sheep
  • Placental flow
  • Placental resistance
  • Systemic flow
  • Systemic resistance

ASJC Scopus subject areas

  • Physiology

Cite this

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abstract = "Six singleton fetal sheep of 118-122 days gestational age were instrumented with flow sensors on the brachiocephalic artery, the postductal aorta, and the common umbilical artery and with arterial and venous intravascular catheters. At 125-131 days of gestation, we started week-long continuous recordings of flows and pressures. After control measures had been obtained, the fetuses were given continuous intravenous infusions of adult sheep plasma at an initial rate of 229 ml/day. After 1 wk of infusion, fetal plasma protein concentrations had increased from 34 to 78 g/l, arterial and venous pressures had increased from 42 to 64 and from 2.7 to 3.7 mmHg, and systemic resistance (exclusive of the coronary bed) had increased from 0.047 to 0.075 mmHg·min -1·ml-1, whereas placental resistance had increased from 0.065 to 0.111 mmHg·min-1·ml-1. Fetal plasma renin activities fell as early as 1 day after the start of infusion and remained below control (all changes P <0.05). All flows decreased slightly although these decreases were not statistically significant. Thus the increase in arterial pressure was entirely due to an increase in systemic and placental resistances.",
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AU - Faber, J. Job

AU - Jonker, Sonnet

AU - Davis, Lowell

AU - Anderson, Debra

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AB - Six singleton fetal sheep of 118-122 days gestational age were instrumented with flow sensors on the brachiocephalic artery, the postductal aorta, and the common umbilical artery and with arterial and venous intravascular catheters. At 125-131 days of gestation, we started week-long continuous recordings of flows and pressures. After control measures had been obtained, the fetuses were given continuous intravenous infusions of adult sheep plasma at an initial rate of 229 ml/day. After 1 wk of infusion, fetal plasma protein concentrations had increased from 34 to 78 g/l, arterial and venous pressures had increased from 42 to 64 and from 2.7 to 3.7 mmHg, and systemic resistance (exclusive of the coronary bed) had increased from 0.047 to 0.075 mmHg·min -1·ml-1, whereas placental resistance had increased from 0.065 to 0.111 mmHg·min-1·ml-1. Fetal plasma renin activities fell as early as 1 day after the start of infusion and remained below control (all changes P <0.05). All flows decreased slightly although these decreases were not statistically significant. Thus the increase in arterial pressure was entirely due to an increase in systemic and placental resistances.

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KW - Systemic flow

KW - Systemic resistance

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