Effects of inspiratory support upon breathing in humans during wakefulness and sleep

M. J. Morrell, S. A. Shea, L. Adams, A. Guz

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

We have compared the effects on breathing of inspiratory mechanical support during wakefulness and sleep in healthy subjects. Nine awake volunteers breathed through a nose mark connected to a machine supplying variable levels of inspiratory positive airway pressure (IPAP). Tidal volume (Vt), breath duration (Ttot) and end-tidal PCO2 (PetCO2) were measured over 1 min steady state periods with IPAP set at a minimal level (approx. 2 cmH2O) and at approx. 10 cmH2O. This protocol was repeated in 6 of the subjects during non-REM sleep. When awake, "10 cmH2O IPAP" caused a significant increase in mean Vt from 513 to 842 ml and a significant fall in PetCO2 from 39.7 to 32.7 mmHg. During sleep, "10 cmH2O IPAP" caused no significant change in Vt (388 tp 390 ml) or PetCO2 (41.8 to 39.8 mmHg). In each state, "10 cmH2O IPAP" had no significant effect on Ttot. Three subjects repeated the protocol with diaphragmatic surface EMG recorded as an index of efferent inspiratory activity. "10 cmH2O IPAP" had no consistent effect on EMG when awake but caused a reduction in each subject during sleep. We conclude that during non-REM sleep, inspiratory mechanical support is associated with a compensatory decrease in efferent inspiratory activity to achieve a similar tidal volume with maintenance of arterial PCO2. When awake, a "wakefulness drive to breathe" may be associated with maintained inspiratory activity such that mechanical support results in an increased tidal volume despite a fall arterial PCO2.

Original languageEnglish (US)
Pages (from-to)57-70
Number of pages14
JournalRespiration Physiology
Volume93
Issue number1
DOIs
StatePublished - Jul 1993

Keywords

  • Control of breathing, inspiratory pressure support, hypocapnia
  • Hypocapnia, inspiratory pressure support
  • Mammals, humans
  • Mechanical ventilation, IPAP, wakefulness vs sleep
  • Sleep, mechanical ventilation

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine

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