Effects of inhalation exposures and intraperitoneal injections of methyl n-amyl ketone on multiple fixed-ratio, fixed-interval response rates in rats

Wyndham Anger, Mary Kay Jordan, Dennis W. Lynch

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Twelve rats were tested daily for 1 hr on a multiple fixed-ratio, fixed-interval schedule of reinforcement. The rats were given ip injections of methyl n-amyl ketone (MAK; 2-heptanone), an industrial solvent, in concentrations ranging from 18 to 175 mg/kg on one to eight occasions each, and were tested 15 min after the injections. When compared to the preceding control (saline) day, there was little or no fixed interval (FI) response rate change at 18 mg/kg, moderate FI rate decreases at 37 and 74 mg/kg and a near cessation of responding at 175 mg/kg MAK. Changes were statistically significant (p

Original languageEnglish (US)
Pages (from-to)407-416
Number of pages10
JournalToxicology and Applied Pharmacology
Volume49
Issue number3
DOIs
StatePublished - 1979
Externally publishedYes

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Inhalation Exposure
Intraperitoneal Injections
Rats
Reinforcement Schedule
Injections
Reinforcement
2-heptanone

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

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