Effects of inflammatory cells on neuronal M2 muscarinic receptor function in the lung

Allison Fryer, Darryl J. Adamko, Bethany L. Yost, David Jacoby

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

In the lungs, acetylcholine released from the parasympathetic nerves stimulates M3 muscarinic receptors on airway smooth muscle inducing contraction and bronchoconstriction. The amount of acetylcholine released from these nerves is limited locally by neuronal M2 muscarinic receptors. These neuronal receptors are dysfunctional in asthma and in animal models of asthma. Decreased M2 muscarinic receptor function results in increased release of acetylcholine and in airway hyperreactivity. Inflammation has long been associated with hyperreactivity and the role of inflammatory cells in loss of neuronal M2 receptor function has been examined. There are several different mechanisms for loss of neuronal M2 receptor function. These include blockade by endogenous antagonists such as eosinophil major basic protein, decreased expression of M2 receptors following infection with viruses or exposure to pro inflammatory cytokines such as gamma interferon. Finally, the affinity of acetylcholine for these receptors can be decreased by exposure to neuraminidase.

Original languageEnglish (US)
Pages (from-to)449-455
Number of pages7
JournalLife Sciences
Volume64
Issue number6-7
DOIs
StatePublished - Jan 8 1999
Externally publishedYes

Fingerprint

Muscarinic M2 Receptors
Acetylcholine
Lung
Eosinophil Major Basic Protein
Asthma
Muscarinic M3 Receptors
Bronchoconstriction
Neuraminidase
Cholinergic Receptors
Virus Diseases
Muscle Contraction
Viruses
Interferon-gamma
Smooth Muscle
Muscle
Animals
Animal Models
Cytokines
Inflammation

Keywords

  • Asthma
  • Eosinophils
  • Hyperreactivity
  • Interferon-γ

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effects of inflammatory cells on neuronal M2 muscarinic receptor function in the lung. / Fryer, Allison; Adamko, Darryl J.; Yost, Bethany L.; Jacoby, David.

In: Life Sciences, Vol. 64, No. 6-7, 08.01.1999, p. 449-455.

Research output: Contribution to journalArticle

Fryer, Allison ; Adamko, Darryl J. ; Yost, Bethany L. ; Jacoby, David. / Effects of inflammatory cells on neuronal M2 muscarinic receptor function in the lung. In: Life Sciences. 1999 ; Vol. 64, No. 6-7. pp. 449-455.
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