Effects of hyperbaric oxygen therapy on hydroxyapatite orbital implant vascularization in rabbits

John Ng, William R. Nunery, Ronald T. Martin, Patti A. Ng, Jose M. Bonnin, A. D. Elkins

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: To determine if hyperbaric oxygen therapy affects the rate of hydroxyapatite orbital implant vascularization in normal rabbit orbits. Methods: We performed a randomized comparative experimental pilot study involving 6 rabbits. All rabbits were enucleated and implanted with hydroxyapatite orbital spheres. The animals were randomized for enucleation of the right or left eye and for treatment or nontreatment (control) with hyperbaric oxygen. The implants were removed after 3 weeks of treatment and histologically examined for fibrovascular ingrowth, inflammation, and multinucleated giant cells. Each parameter was graded on a numeric scale and analyzed. Results: Hyperbaric oxygen therapy did not increase implant vascularization compared with nontreatment implants. Although treated implants had less central fibrovascular maturity compared with control implants, the difference was not statistically significant (p <0.055). There was no significant difference in inflammation or the number of multinucleated giant cells between treated and control implants. Conclusions: In this pilot study, hyperbaric oxygen therapy did not increase hydroxyapatite vascular ingrowth and possibly delayed fibrovascular maturation in normal sockets. Further studies with more subject numbers are needed to confirm these conclusions. The effect of hyperbaric oxygen therapy in vascularly compromised sockets also needs to be determined.

Original languageEnglish (US)
Pages (from-to)254-263
Number of pages10
JournalOphthalmic Plastic and Reconstructive Surgery
Volume17
Issue number4
StatePublished - 2001

Fingerprint

Orbital Implants
Hyperbaric Oxygenation
Durapatite
Rabbits
Giant Cells
Inflammation
Orbit
Blood Vessels
Oxygen
Therapeutics

ASJC Scopus subject areas

  • Ophthalmology
  • Surgery

Cite this

Ng, J., Nunery, W. R., Martin, R. T., Ng, P. A., Bonnin, J. M., & Elkins, A. D. (2001). Effects of hyperbaric oxygen therapy on hydroxyapatite orbital implant vascularization in rabbits. Ophthalmic Plastic and Reconstructive Surgery, 17(4), 254-263.

Effects of hyperbaric oxygen therapy on hydroxyapatite orbital implant vascularization in rabbits. / Ng, John; Nunery, William R.; Martin, Ronald T.; Ng, Patti A.; Bonnin, Jose M.; Elkins, A. D.

In: Ophthalmic Plastic and Reconstructive Surgery, Vol. 17, No. 4, 2001, p. 254-263.

Research output: Contribution to journalArticle

Ng, J, Nunery, WR, Martin, RT, Ng, PA, Bonnin, JM & Elkins, AD 2001, 'Effects of hyperbaric oxygen therapy on hydroxyapatite orbital implant vascularization in rabbits', Ophthalmic Plastic and Reconstructive Surgery, vol. 17, no. 4, pp. 254-263.
Ng, John ; Nunery, William R. ; Martin, Ronald T. ; Ng, Patti A. ; Bonnin, Jose M. ; Elkins, A. D. / Effects of hyperbaric oxygen therapy on hydroxyapatite orbital implant vascularization in rabbits. In: Ophthalmic Plastic and Reconstructive Surgery. 2001 ; Vol. 17, No. 4. pp. 254-263.
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N2 - Purpose: To determine if hyperbaric oxygen therapy affects the rate of hydroxyapatite orbital implant vascularization in normal rabbit orbits. Methods: We performed a randomized comparative experimental pilot study involving 6 rabbits. All rabbits were enucleated and implanted with hydroxyapatite orbital spheres. The animals were randomized for enucleation of the right or left eye and for treatment or nontreatment (control) with hyperbaric oxygen. The implants were removed after 3 weeks of treatment and histologically examined for fibrovascular ingrowth, inflammation, and multinucleated giant cells. Each parameter was graded on a numeric scale and analyzed. Results: Hyperbaric oxygen therapy did not increase implant vascularization compared with nontreatment implants. Although treated implants had less central fibrovascular maturity compared with control implants, the difference was not statistically significant (p <0.055). There was no significant difference in inflammation or the number of multinucleated giant cells between treated and control implants. Conclusions: In this pilot study, hyperbaric oxygen therapy did not increase hydroxyapatite vascular ingrowth and possibly delayed fibrovascular maturation in normal sockets. Further studies with more subject numbers are needed to confirm these conclusions. The effect of hyperbaric oxygen therapy in vascularly compromised sockets also needs to be determined.

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