Effects of hyperandrogenemia and increased adiposity on reproductive and metabolic parameters in young adult female monkeys

W. K. McGee, Cecily Bishop, C. R. Pohl, R. J. Chang, J. C. Marshall, F. K. Pau, Richard Stouffer, J. L. Cameron

    Research output: Contribution to journalArticle

    23 Citations (Scopus)

    Abstract

    Many patients with hyperandrogenemia are overweight or obese, which exacerbates morbidities associated with polycystic ovary syndrome (PCOS). To examine the ability of testosterone (T) to generate PCOS-like symptoms, monkeys received T or cholesterol (control) implants (n = 6/group) beginning prepubertally. As previously reported, T-treated animals had increased neuroendocrine drive to the reproductive axis [increased luteinizing hormone (LH) pulse frequency] at 5 yr, without remarkable changes in ovarian or metabolic features. To examine the combined effects of T and obesity, at 5.5 yr (human equivalent age: 17 yr), monkeys were placed on a high-calorie, high-fat diet typical of Western cultures [Western style diet (WSD)], which increased body fat from

    Original languageEnglish (US)
    JournalAmerican Journal of Physiology - Endocrinology and Metabolism
    Volume306
    Issue number11
    DOIs
    StatePublished - Jun 1 2014

    Fingerprint

    Polycystic Ovary Syndrome
    Adiposity
    Haplorhini
    Young Adult
    High Fat Diet
    Luteinizing Hormone
    Testosterone
    Adipose Tissue
    Obesity
    Cholesterol
    Diet
    Morbidity

    Keywords

    • Amenorrhea
    • Insulin insensitivity
    • Obesity
    • Ovarian follicle
    • Testosterone

    ASJC Scopus subject areas

    • Physiology
    • Physiology (medical)
    • Endocrinology, Diabetes and Metabolism

    Cite this

    Effects of hyperandrogenemia and increased adiposity on reproductive and metabolic parameters in young adult female monkeys. / McGee, W. K.; Bishop, Cecily; Pohl, C. R.; Chang, R. J.; Marshall, J. C.; Pau, F. K.; Stouffer, Richard; Cameron, J. L.

    In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 306, No. 11, 01.06.2014.

    Research output: Contribution to journalArticle

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