Effects of growth hormone-releasing factor on growth hormone secretion in acromegaly

Marie C. Gelato, George R. Merriam, Mary L. Vance, James A. Goldman, Cheryle Webb, William S. Evans, Jack Rock, Edward H. Oldfield, Mark E. Molitch, Jean Rivier, Wylie Vale, Seymour Reichlin, Lawrence A. Frohman, D. Lynn Loriaux, Michael O. Thorner

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Twenty-nine patients with acromegaly (8 un treated and 21 previously treated in various ways) and 16 normal men were given iv bolus doses of human pancreatic tumor GH-releasing factor (hpGRF-40). Twenty-five of the 29 patients responded to hpGRF-40 with elevations of plasma GH. The magnitude of the responses varied widely. Responses of untreated patients were generally similar to those of the normal subjects. Previously treated patients had a significantly lower response than normal individuals [change in GH, 7.5 ±1.8 vs. 42.0 ± 11.0 ng/ml (mean ± SEM); P < 0.01], and 4 patients whohad received radiation therapy failed to respond to hpGRF-40. There was no significant correlation between the magnitude of the response and patients’ age, sex, baseline GH levels, GH responsiveness of TRH, or GH suppression after oral glucose administration. Patients studied both pre- and postoperatively were responsive to hpGRF-40 at all times tested, but the magnitude of the response decreased after successful surgical removal of the adenoma. Thus, most patients with treated or untreated acromegaly respond to hpGRF-40, but their responses do not clearly distinguish them from normal subjects. GH-releasing hormone testing isunlikely to replace other endocrine tests available for the diagnosis and evaluation of acromegaly.

Original languageEnglish (US)
Pages (from-to)251-257
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume60
Issue number2
DOIs
StatePublished - Feb 1985

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ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Gelato, M. C., Merriam, G. R., Vance, M. L., Goldman, J. A., Webb, C., Evans, W. S., Rock, J., Oldfield, E. H., Molitch, M. E., Rivier, J., Vale, W., Reichlin, S., Frohman, L. A., Loriaux, D. L., & Thorner, M. O. (1985). Effects of growth hormone-releasing factor on growth hormone secretion in acromegaly. Journal of Clinical Endocrinology and Metabolism, 60(2), 251-257. https://doi.org/10.1210/jcem-60-2-251