TY - JOUR
T1 - Effects of free fatty acids, ethanol and development on γ-aminobutyric acid and glutamate fluxes in rat nerve endings
AU - Hitzemann, Robert
AU - Mark, Cynthia
AU - Panini, Aruna
PY - 1982/12/15
Y1 - 1982/12/15
N2 - The effects of type A (cis-unsaturated) and type B (trans-unsaturated and saturated) fatty acids, 1% and 3% ethanol (v/v), and development (7 days) on the thermodynamics of glutamate and γ-aminobutyric acid (GABA) transport into cortical rat brain nerve endings were examined. The effects of the various manipulations, which are known to affect membrane fluidity, may be summarized. Three percent ethanol and oleic acid increased ΔS° and ΔS† for glutamate transport and decreased ΔH° and ΔH†. Type B fatty acids had the opposite effects. In comparison to glutamate transport, GABA transport was less affected by the various manipulations and showed less specificity in terms of the fatty acid effects. Similarly, the effects of development on the thermodynamic parameters for glutamate and GABA transport were not consistent. Glutamate transport into 7-day nerve endings showed thermodynamic behavior similar to that seen when type A fatty acids were incorporated into adult nerve endings. In contrast, GABA transport into 7-day nerve endings had the character of adult nerve endings into which type B fatty acids were incorporated.
AB - The effects of type A (cis-unsaturated) and type B (trans-unsaturated and saturated) fatty acids, 1% and 3% ethanol (v/v), and development (7 days) on the thermodynamics of glutamate and γ-aminobutyric acid (GABA) transport into cortical rat brain nerve endings were examined. The effects of the various manipulations, which are known to affect membrane fluidity, may be summarized. Three percent ethanol and oleic acid increased ΔS° and ΔS† for glutamate transport and decreased ΔH° and ΔH†. Type B fatty acids had the opposite effects. In comparison to glutamate transport, GABA transport was less affected by the various manipulations and showed less specificity in terms of the fatty acid effects. Similarly, the effects of development on the thermodynamic parameters for glutamate and GABA transport were not consistent. Glutamate transport into 7-day nerve endings showed thermodynamic behavior similar to that seen when type A fatty acids were incorporated into adult nerve endings. In contrast, GABA transport into 7-day nerve endings had the character of adult nerve endings into which type B fatty acids were incorporated.
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U2 - 10.1016/0006-2952(82)90653-0
DO - 10.1016/0006-2952(82)90653-0
M3 - Article
C2 - 6130769
AN - SCOPUS:0020466718
SN - 0006-2952
VL - 31
SP - 4039
EP - 4044
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
IS - 24
ER -