Effects of fish oil on VLDL triglyceride kinetics in humans

William Harris, W. E. Connor, D. R. Illingworth, D. W. Rothrock, D. M. Foster

Research output: Contribution to journalArticle

173 Citations (Scopus)

Abstract

Dietary n-3 fatty acids (FAs) found in fish oils markedly lower plasma triglyceride (TG) and very low density lipoprotein (VLDL) levels in both normal and hypertriglyceridemic subjects. The present study examined the mechanism of this effect. Ten subjects with widely different plasma triglyceride levels (82 to 1002 mg/dl) were fed metabolically controlled diets containing 20% fat. The control diet contained a blend of cocoa butter and peanut oil (P/S = 0.8). The test diet contained fish oil (P/S = 1.1) and provided 10-17 g of n-3 FAs per day (depending on calorie intake). After 3 to 5 weeks of each diet, the kinetics of VLDL-TG were determined over a 48-h period after the injection of [3H]glycerol. The fish oil diet reduced the VLDL-TG synthetic rate from 23 ± 14.3 (mean ± SD) to 12.6 ± 7.5 mg/h per kg ideal weight (P

Original languageEnglish (US)
Pages (from-to)1549-1558
Number of pages10
JournalJournal of Lipid Research
Volume31
Issue number9
StatePublished - 1990
Externally publishedYes

Fingerprint

Fish Oils
Nutrition
Diet
Kinetics
Omega-3 Fatty Acids
Plasmas
Glycerol
Triglycerides
Fats
very low density lipoprotein triglyceride
Weights and Measures
Injections

Keywords

  • fractional catabolic rate
  • n-3 fatty acids

ASJC Scopus subject areas

  • Endocrinology

Cite this

Harris, W., Connor, W. E., Illingworth, D. R., Rothrock, D. W., & Foster, D. M. (1990). Effects of fish oil on VLDL triglyceride kinetics in humans. Journal of Lipid Research, 31(9), 1549-1558.

Effects of fish oil on VLDL triglyceride kinetics in humans. / Harris, William; Connor, W. E.; Illingworth, D. R.; Rothrock, D. W.; Foster, D. M.

In: Journal of Lipid Research, Vol. 31, No. 9, 1990, p. 1549-1558.

Research output: Contribution to journalArticle

Harris, W, Connor, WE, Illingworth, DR, Rothrock, DW & Foster, DM 1990, 'Effects of fish oil on VLDL triglyceride kinetics in humans', Journal of Lipid Research, vol. 31, no. 9, pp. 1549-1558.
Harris W, Connor WE, Illingworth DR, Rothrock DW, Foster DM. Effects of fish oil on VLDL triglyceride kinetics in humans. Journal of Lipid Research. 1990;31(9):1549-1558.
Harris, William ; Connor, W. E. ; Illingworth, D. R. ; Rothrock, D. W. ; Foster, D. M. / Effects of fish oil on VLDL triglyceride kinetics in humans. In: Journal of Lipid Research. 1990 ; Vol. 31, No. 9. pp. 1549-1558.
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