Effects of exogenous melatonin administration and withdrawal in five patients with rapid-cycling bipolar disorder

Ellen Leibenluft, Susana Feldman-Naim, Erick Turner, Thomas A. Wehr, Norman E. Rosenthal

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Background: The ready availability of exogenous melatonin means that its use in patients with mood disorders is probably not uncommon. Nonetheless, few controlled trials of exogenous melatonin in these patients have been conducted. Method: Five patients with rapid-cycling DSM-III-R bipolar disorder were treated with melatonin 10 mg q.d. at 10:00 p.m. for 12 weeks. Melatonin was added to a stable regimen of medication and administered in a double-blind, placebo-controlled fashion. Results: Melantonin administration had no positive effects. One patient developed a free-running (unentrained) sleep-wake cycle after melatonin withdrawal. In addition, in both this and a second patient, there is evidence that the administration of exogenous melatonin may have suppressed the secretion of endogenous melatonin. Conclusion: The administration of melatonin had no significant effects on mood or sleep. However, melatonin withdrawal delayed sleep onset time and may have had some mild mood-elevating effects.

Original languageEnglish (US)
Pages (from-to)383-388
Number of pages6
JournalJournal of Clinical Psychiatry
Volume58
Issue number9
StatePublished - 1997
Externally publishedYes

Fingerprint

Melatonin
Bipolar Disorder
Sleep
Mood Disorders
Diagnostic and Statistical Manual of Mental Disorders
Placebos

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Effects of exogenous melatonin administration and withdrawal in five patients with rapid-cycling bipolar disorder. / Leibenluft, Ellen; Feldman-Naim, Susana; Turner, Erick; Wehr, Thomas A.; Rosenthal, Norman E.

In: Journal of Clinical Psychiatry, Vol. 58, No. 9, 1997, p. 383-388.

Research output: Contribution to journalArticle

Leibenluft, Ellen ; Feldman-Naim, Susana ; Turner, Erick ; Wehr, Thomas A. ; Rosenthal, Norman E. / Effects of exogenous melatonin administration and withdrawal in five patients with rapid-cycling bipolar disorder. In: Journal of Clinical Psychiatry. 1997 ; Vol. 58, No. 9. pp. 383-388.
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