Effects of exogenous melatonin administration and withdrawal in five patients with rapid-cycling bipolar disorder

Ellen Leibenluft, Susana Feldman-Naim, Erick H. Turner, Thomas A. Wehr, Norman E. Rosenthal

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Background: The ready availability of exogenous melatonin means that its use in patients with mood disorders is probably not uncommon. Nonetheless, few controlled trials of exogenous melatonin in these patients have been conducted. Method: Five patients with rapid-cycling DSM-III-R bipolar disorder were treated with melatonin 10 mg q.d. at 10:00 p.m. for 12 weeks. Melatonin was added to a stable regimen of medication and administered in a double-blind, placebo-controlled fashion. Results: Melantonin administration had no positive effects. One patient developed a free-running (unentrained) sleep-wake cycle after melatonin withdrawal. In addition, in both this and a second patient, there is evidence that the administration of exogenous melatonin may have suppressed the secretion of endogenous melatonin. Conclusion: The administration of melatonin had no significant effects on mood or sleep. However, melatonin withdrawal delayed sleep onset time and may have had some mild mood-elevating effects.

Original languageEnglish (US)
Pages (from-to)383-388
Number of pages6
JournalJournal of Clinical Psychiatry
Volume58
Issue number9
DOIs
StatePublished - Jan 1 1997

ASJC Scopus subject areas

  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'Effects of exogenous melatonin administration and withdrawal in five patients with rapid-cycling bipolar disorder'. Together they form a unique fingerprint.

  • Cite this