Effects of ethanol on calcium homeostasis in the nervous system: Implications for astrocytes

Michelle C. Catlin, Marina Guizzetti, Lucio G. Costa

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Ethanol is a major health concern, with neurotoxicity occurring after both in utero exposure and adult alcohol abuse. Despite a large amount of research, the mechanism(s) underlying the neurotoxicity of ethanol remain unknown. One of the cellular aspects that has been investigated in relationship to the neuroteratogenicity and neurotoxicity of ethanol is the maintenance of calcium homeostasis. Studies in neuronal cells and other cells have shown that ethanol can alter intracellular calcium levels and affect voltage and receptor-operated calcium channels, as well as G protein-mediated calcium responses. Despite increasing evidence of the important roles of glial cells in the nervous systems, few studies exist on the potential effects of ethanol on calcium homeostasis in these cells. This brief review discusses a number of reported effects of alcohol on calcium responses that may be relevant to astrocytes' functions.

Original languageEnglish (US)
Pages (from-to)1-24
Number of pages24
JournalMolecular Neurobiology
Volume19
Issue number1
StatePublished - 1999
Externally publishedYes

Fingerprint

Astrocytes
Nervous System
Homeostasis
Ethanol
Calcium
Calcium Channels
GTP-Binding Proteins
Neuroglia
Alcoholism
Maintenance
Alcohols
Health
Research

Keywords

  • Alcohol tolerance
  • Astrocytes
  • Calcium
  • Calcium channels
  • Ethanol
  • Fetal alcohol syndrome
  • G proteins
  • Nervous system

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

Cite this

Effects of ethanol on calcium homeostasis in the nervous system : Implications for astrocytes. / Catlin, Michelle C.; Guizzetti, Marina; Costa, Lucio G.

In: Molecular Neurobiology, Vol. 19, No. 1, 1999, p. 1-24.

Research output: Contribution to journalArticle

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